Strategic Plan for Lung Vascular Research An NHLBI-ORDR Workshop Report
Strategic Plan for Lung Vascular Research An NHLBI-ORDR Workshop Report
复制标题
DOI：
10.1164/rccm.201006-0869ws
复制
发表时间：
2010-12-15
影响因子：
24.7
通讯作者：
Moore, Timothy M.
中科院分区：
文献类型：
--
作者：
Erzurum, Serpil;Rounds, Sharon I.;Moore, Timothy M.
国家心脏，肺和血液研究所肺部疾病部门与罕见疾病研究办公室举行了一次研讨会，以确定优先领域和战略目标，以加强和加速研究，从而提高对肺血管系统的理解，转化研究需求，并最终照顾肺血管疾病患者。在实验室，转化和临床研究方面具有不同经验的多学科专家确定了七个优先领域，并讨论了我们现有知识，技术和方法的局限性。未来的研究重点包括：（1）更好地表征血管基因型表型关系，并在适当的时候引入系统生物学方法;（2）提高我们对健康和疾病中肺血管代谢调节信号的理解;（3）扩大我们对肺循环与循环要素、全身血管功能、和右心功能和疾病;（4）改进转化研究以确定肺动脉高压疾病的疾病改善疗法;（5）建立适当和有效的平台以将转化发现推进临床研究测试;以及（6）开发将实现这些目标的特定技术和工具，例如问题引导成像技术和肺血管研究者培训计划。本次研讨会的建议将用于肺血管生物学和疾病校外研究计划的规划和战略实施的目的。
The Division of Lung Diseases of the National Heart, Lung, and Blood Institute, with the Office of Rare Diseases Research, held a workshop to identify priority areas and strategic goals to enhance and accelerate research that will result in improved understanding of the lung vasculature, translational research needs, and ultimately the care of patients with pulmonary vascular diseases. Multidisciplinary experts with diverse experience in laboratory, translational, and clinical studies identified seven priority areas and discussed limitations in our current knowledge, technologies, and approaches. The focus for future research efforts include the following: (1) better characterizing vascular genotype phenotype relationships and incorporating systems biology approaches when appropriate; (2) advancing our understanding of pulmonary vascular metabolic regulatory signaling in health and disease; (3) expanding our knowledge of the biologic relationships between the lung circulation and circulating elements, systemic vascular function, and right heart function and disease; (4) improving translational research for identifying disease-modifying therapies for the pulmonary hypertensive diseases; (5) establishing an appropriate and effective platform for advancing translational findings into clinical studies testing; and (6) developing the specific technologies and tools that will be enabling for these goals, such as question-guided imaging techniques and lung vascular investigator training programs. Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes.