Contemporary Risk Profile of Prostate Cancer in the United States
Contemporary Risk Profile of Prostate Cancer in the United States
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DOI：
10.1093/jnci/djp262
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发表时间：
2009-09-16
影响因子：
10.3
通讯作者：
Lu-Yao, Grace L.
中科院分区：
文献类型：
--
作者：
Shao, Yu-Hsuan;Demissie, Kitaw;Lu-Yao, Grace L.
表征当代前列腺癌患者的国家级数据有限。我们使用了2004-2005年的监测、流行病学和最终结果项目的数据，以生成前列腺癌患者的当代概况（N = 82541），并将2004-2005年人群的患者特征与1998-1989年和1996-1997年诊断的患者特征进行了比较。在2004-2005年新诊断的患者中，大多数（94%）患有局限性（即T1或T2期）前列腺癌，中位血清前列腺特异性抗原（PSA）水平为6.7 ng/mL。在1988-1989年和2004-2005年之间，前列腺癌诊断的平均年龄从72.2岁下降到67.2岁，T3或T4癌症的发病率在白人中从每10万人52.7例下降到每10万人7.9例，在黑人中从每10万人90.9例下降到每10万人13.3例。2004-2005年，与白人相比，黑人更容易在更年轻的时候被诊断出来（平均年龄：64.7 vs 67.5岁，差异= 2.7岁，95%置信区间[CI] = 2.5 - 2.9岁，P < .001），诊断时PSA水平较高（中位PSA水平：7.4 vs 6.6 ng/mL，差异= 0.8 ng/mL，95% CI = 0.6 - 1.0 ng/mL，P < .001）。总之，2004-2005年诊断出前列腺癌的男子比前几年更年轻，更早。随着时间的推移，诊断时癌症分期的种族差异在统计学上显著减少。
National-level data that characterize contemporary prostate cancer patients are limited. We used 2004-2005 data from the Surveillance, Epidemiology, and End Results Program to generate a contemporary profile of prostate cancer patients (N = 82541) and compared patient characteristics of this 2004-2005 population with those of patients diagnosed in 1998-1989 and 1996-1997. Among newly diagnosed patients in 2004-2005, the majority (94%) had localized (ie, stage T1 or T2) prostate cancer and a median serum prostate-specific antigen (PSA) level of 6.7 ng/mL. Between 1988-1989 and 2004-2005, the average age at prostate cancer diagnosis decreased from 72.2 to 67.2 years, and the incidence rate of T3 or T4 cancer decreased from 52.7 per 100000 to 7.9 per 100000 among whites and from 90.9 per 100000 to 13.3 per 100000 among blacks. In 2004-2005, compared with whites, blacks were more likely to be diagnosed at a younger age (mean age: 64.7 vs 67.5 years, difference = 2.7 years, 95% confidence interval [CI] = 2.5 to 2.9 years, P < .001) and to have a higher PSA level at diagnosis (median PSA level: 7.4 vs 6.6 ng/mL, difference = 0.8 ng/mL, 95% CI = 0.6 to 1.0 ng/mL, P < .001). In conclusion, more men were diagnosed with prostate cancer at a younger age and earlier stage in 2004-2005 than in earlier years. The racial disparity in cancer stage at diagnosis has decreased statistically significantly over time.