A NEW FAMILY OF MOUSE HOMEO BOX-CONTAINING GENES - MOLECULAR-STRUCTURE, CHROMOSOMAL LOCATION, AND DEVELOPMENTAL EXPRESSION OF HOX-7.1
A NEW FAMILY OF MOUSE HOMEO BOX-CONTAINING GENES - MOLECULAR-STRUCTURE, CHROMOSOMAL LOCATION, AND DEVELOPMENTAL EXPRESSION OF HOX-7.1
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DOI：
10.1101/gad.3.1.26
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发表时间：
1989-01-01
影响因子：
10.5
通讯作者：
DAVIDSON, DR
中科院分区：
文献类型：
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作者：
HILL, RE;JONES, PF;DAVIDSON, DR
迄今为止，基于与果蝇基因序列的相似性，已经在哺乳动物中发现了两个包含同源盒的基因家族，即触角状和嵌入状同源盒。在这里，我们报道了一个同源盒基因的分离，该基因属于一个新的家族，其中在小鼠基因组中至少有三个相关基因。这个新基因的同源盒与果蝇的Msh同源盒非常相似，我们将其称为这个家族的原型。该基因位于小鼠5号染色体的近端，不与任何已知的同源盒基因共分离。我们将此位点命名为Hox-7.1。与迄今为止描述的其他同源盒基因相比，不同阶段小鼠胚胎的原位杂交显示出独特的表达模式。在9.5日龄的神经嵴、发育中的肢体芽和内脏弓的胚胎中检测到Hox-7.1转录本。随后，该基因在面部来源于神经嵴的区域以及前肢和后肢的指间质组织中表达。
Two families of homeo box-containing genes have been identified in mammals to date, the Antennapedia- and engrailed-like homeo boxes, based on the sequence similarity to those from Drosophila. Here, we report the isolation of a homeo box-containing gene that belong to a new family of which there are at least three related genes in the mouse genome. The homeo box of this new gene shows remarkable similarity to the Drosophila Msh homeo box that we designate as the prototype for this family. The gene maps to the proximal end of mouse chromosome 5 and does not cosegregate with any known homeo box-containing gene. We designate this locus Hox-7.1. In situ hybridizations to mouse embryos at different stages show a unique pattern of expression, as compared to other homeo box-containing gene described thus far. Hox-7.1 transcripts are detected in 9.5-day-old embryos in the neural crest, developing limb bud, and visceral arches. Later, this gene is expressed in regions of the face that are derived from neural crest and in the interdigital mesenchymal tissue in both the fore- and hindlimbs.