Relationship between Hypercoagulable State and Circulating Tumor Cells in Peripheral Blood, Pathological Characteristics, and Prognosis of Lung Cancer Patients.
Relationship between Hypercoagulable State and Circulating Tumor Cells in Peripheral Blood, Pathological Characteristics, and Prognosis of Lung Cancer Patients.
复制标题
在外周血，病理特征和肺癌患者预后中，高凝状态与循环肿瘤细胞之间的关系。
DOI：
10.1155/2021/5732222
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Hu T
中科院分区：
文献类型：
--
作者：
Jiao Y;Guo L;Wu L;Hu T
To analyze the relationship between hypercoagulable state and circulating tumor cells (CTCs) in peripheral blood, pathological characteristics, and prognosis of lung cancer patients. A total of 148 patients with primary lung cancer diagnosed and treated in our hospital from January 2017 to January 2019 were selected as the research objects. According to the CTC test results, the patients were divided into CTC-positive group and CTC-negative group. Also, the coagulation index of patients was tested. According to the blood coagulation index test results, patients were divided into hypercoagulable group and non-hypercoagulable group. The relationship between hypercoagulable state and pathological characteristics of lung cancer patients was analyzed by single factor analysis and multiple logistic regression model. Kaplan–Meier survival curve was applied to analyze the relationship between hypercoagulable state and the prognosis of lung cancer patients. The platelets (PLTs), fibrinogen (FIB), D-dimer (D-D), and prothrombin time (PT) in CTC-positive group were significantly higher than those in CTC-negative group. There was no significant relationship between the patient's gender, smoking history, pathological type, and the hypercoagulable state of the patients. The proportion of patients aged 60 years or older, with TMN stage III or IV and lymph node metastasis, in the hypercoagulable group was significantly higher than that in the non-hypercoagulable group. Logistic regression analysis showed that there was an independent relationship between the patient's age, lymph node metastasis, and hypercoagulable state. As of January 2020, among the 148 patients with lung cancer follow-up, 5 patients were lost and 52 died. The median survival time of patients in the hypercoagulable group was 82 weeks, which was significantly lower than the 104 weeks in the nonhypercoagulable group. There is a certain relationship between hypercoagulable state and CTC positive in lung cancer patients. There is an independent relationship between the patient's age, lymph node metastasis, and the hypercoagulable state. The median survival time of patients in the hypercoagulable group was significantly lower than that in the non-hypercoagulable group.
登录
查看更多内容
暴露于磷脂酰丝氨酸的血液和内皮细胞导致原发性血小板增多症患者的高凝状态。
影响因子：
3.5
作者：
Tong, Dongxia;Yu, Muxin;Shi, Jialan
通讯作者：
Shi, Jialan
影响因子：
3.3
作者：
Nissen, Peter H.;Wulff, Dorte E.;Hvas, Anne-Mette
通讯作者：
Hvas, Anne-Mette
影响因子：
3.7
作者：
Meikle, Claire K.;Meisler, Adam J.;Worth, Randall G.
通讯作者：
Worth, Randall G.
肿瘤特异性组织因子沉默可抑制转移并预防癌症相关的高凝状态
影响因子：
10.8
作者：
Liu, Shaoli;Zhang, Yinlong;Nie, Guangjun
通讯作者：
Nie, Guangjun
影响因子：
2.9
作者：
Nakano, Kentaro;Sugiyama, Kumiya;Fukushima, Yasutsugu
通讯作者：
Fukushima, Yasutsugu