Differentiation-inducing effects of small fruit juices on HL-60 leukemic cells.
Differentiation-inducing effects of small fruit juices on HL-60 leukemic cells.
复制标题
小果汁对 HL-60 白血病细胞的分化诱导作用。
DOI：
10.1021/jf9908650
复制
发表时间：
2000
影响因子：
6.1
通讯作者：
H. Nishimura
中科院分区：
文献类型：
--
作者：
Y. Yoshizawa;S. Kawaii;M. Urashima;T. Fukase;T. Sato;N. Murofushi;H. Nishimura
流行病学研究表明，水果和蔬菜的高摄入量与癌症风险的降低有关，并且已经在内科肿瘤学中开发了几种植物衍生药物。由于只有一小部分植物被测试过任何一种生物活性，我们选择小水果作为对HL-60白血病细胞的分化诱导活性来源。我们用主要生长在日本北部的各种小水果制作果汁。对43个样品的筛选结果表明，猕猴桃、玫瑰、越橘、山茶的汁液含量较高。组织化学和生化检测显示，HL-60细胞以浓度依赖的方式强烈诱导分化为单核/巨噬细胞。
Epidemiological studies indicate that high intakes of fruits and vegetables are associated with a reduced risk of cancer, and several plant-derived drugs have been developed in medical oncology. Since only a small part of the flora has been tested for any kind of bioactivity, we chose small fruits as sources of differentiation-inducing activity against HL-60 leukemic cells. We have prepared juices from various small fruits that grow mainly in the northern part of Japan. Screening of 43 samples indicated that juices of Actinidia polygama Maxim., Rosa rugosa Thunb., Vaccinium smallii A. Gray, and Sorbus sambucifolia Roem. strongly induced differentiation of HL-60 cells to monocyte/macrophage characteristics in a concentration-dependent manner as indicated by histochemical and biochemical examinations.