Neuropilin 1: A Novel Entry Factor for SARS-CoV-2 Infection and a Potential Therapeutic Target.
Neuropilin 1: A Novel Entry Factor for SARS-CoV-2 Infection and a Potential Therapeutic Target.
复制标题
Neuropilin 1：SARS-CoV-2感染的新进入因子和潜在的治疗靶点。
DOI：
10.2147/btt.s307352
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Asmamaw Dejenie T
中科院分区：
文献类型：
--
作者：
Chekol Abebe E;Mengie Ayele T;Tilahun Muche Z;Asmamaw Dejenie T
2019年新型冠状病毒病（COVID-19）大流行严重挑战了世界卫生保健系统和经济，迫切需要开发疫苗和治疗方法来对抗严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）。因此，进一步了解SARS-CoV-2的全面进入机制，特别是促进病毒感染的宿主因素，对于发现有效的疫苗和抗病毒药物至关重要。先前有文献记载，SARS-CoV-2通过与宿主细胞中的ACE2和CD147受体结合到达细胞，这些受体与SARS-CoV-2的刺突(S)蛋白相互作用。最近发现了一种名为neuropilin 1（NRP1）的新型进入因子，它是一种促进SARS-CoV-2进入的共同受体。NRP1是一种单遍跨膜糖蛋白，广泛分布于机体各组织，作为多功能共受体与不同配体蛋白结合，在包括COVID-19在内的不同临床病症/疾病中发挥多种生理、病理和治疗作用。因此，本文简要综述了SARS-CoV-2进入机制、NRP1的结构及其在健康和各种疾病中的作用，并广泛讨论了NRP1在SARS-CoV-2进入和COVID-19治疗中的潜在意义。
The novel coronavirus disease 2019 (COVID-19) pandemic is severely challenging the healthcare systems and economies of the world, which urgently demand vaccine and therapy development to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hence, advancing our understanding of the comprehensive entry mechanisms of SARS-CoV-2, especially the host factors that facilitate viral infection, is crucial for the discovery of effective vaccines and antiviral drugs. SARS-CoV-2 has previously been documented to reach cells by binding with ACE2 and CD147 receptors in host cells that interact with the spike (S) protein of SARS-CoV-2. A novel entry factor, called neuropilin 1(NRP1), has recently been discovered as a co-receptor facilitating the entry of SARS-CoV-2. NRP1 is a single-pass transmembrane glycoprotein widely distributed throughout the tissues of the body and acts as a multifunctional co-receptor to bind with different ligand proteins and play diverse physiological roles as well as pathological and therapeutic roles in different clinical conditions/diseases, including COVID-19. The current review, therefore, briefly provides the overview of SARS-CoV-2 entry mechanisms, the structure of NRP1, and their roles in health and various diseases, as well as extensively discusses the current understanding of the potential implication of NRP1 in SARS-CoV-2 entry and COVID-19 treatment.