Immunolocalization of proliferating cell nuclear antigen in the peri-implant epithelium.
Immunolocalization of proliferating cell nuclear antigen in the peri-implant epithelium.
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发表时间：
1997-08
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通讯作者：
Takashi Inoue;T. Takeda;Lee Cy;Y. Abiko;Y. Ayukawa;T. Tanaka;Masao Yoshinari;Masaki Shimono
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作者：
Takashi Inoue;T. Takeda;Lee Cy;Y. Abiko;Y. Ayukawa;T. Tanaka;Masao Yoshinari;Masaki Shimono
本研究的目的是使用增殖细胞核抗原（PCNA）通过免疫组织化学研究种植体周围上皮的增殖活性。拔牙两个月后，将八颗 ITI（国际种植学团队）种植体植入两只比格犬下颌骨的模拟牙槽中。 As a control, junctional epithelium of the molar teeth in the same animals were used.通过对每个植入物的两个切片上至少 100 个细胞进行评分来确定染色的性质和 PCNA 免疫反应性的分布。在交界上皮中，PCNA 的免疫反应性主要在基底细胞、一些棘细胞和少数附着于牙釉质的细胞中检测到。在种植体周围上皮中，只有部分基底细胞 PCNA 呈阳性。种植体周围上皮的PCNA评分显着低于交界上皮。这些结果表明，种植体周围上皮作为增殖防御机制的能力比连接上皮低。
The aim of the present study was to investigate the proliferating activity of peri-implant epithelium immunohistochemically using proliferating cell nuclear antigen (PCNA). Eight ITI (Internationale Team für Implantologie) implants were placed into simulated sockets in the mandibles of two beagle dogs two months following tooth extraction. As a control, junctional epithelium of the molar teeth in the same animals were used. The nature of staining and the distribution of PCNA immunoreactivity were determined by scoring a minimum of 100 cells on two sections from each of the implants. In the junctional epithelium, the immunoreactivity to PCNA was detected mainly in the basal cells, in some of the prickle cells, and in a few cells attached to the enamel. In peri-implant epithelium, only some of the basal cells were positive for PCNA. The PCNA score of the peri-implant epithelium was significantly lower than that of junctional epithelium. These results suggest that the peri-implant epithelium maintains a lower capacity to act as a proliferative defence mechanism than does the junctional epithelium.