FIBRIN PROMOTION AND LYSIS IN ARTHRITIC JOINTS
FIBRIN PROMOTION AND LYSIS IN ARTHRITIC JOINTS
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DOI：
10.1136/ard.26.3.206
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发表时间：
1967-01-01
影响因子：
27.4
通讯作者：
BLUHM, GB
中科院分区：
文献类型：
--
作者：
BARNHART, MI;RIDDLE, JM;BLUHM, GB
人们对血管外凝血和纤溶的重要性了解甚少。关节炎为研究这些事件提供了一个独特的机会，关节液体可以反映炎症的存在和程度。这份关于144种病理液体的报告扩展了我们对炎症生物化学的认识。此外，它可能为理解关节炎的作用机制提供比目前可用的更有指导意义的基础。纤维蛋白沉积作为永久性关节损伤的一个因素必须认真考虑。滑膜液是一种复杂的混合物，主要来源于血浆，但也是滑膜细胞和血管外白细胞的产物和受体（Ropes和Bauer， 1953）。蛋白质占滑液的1* 4%至5* 6%，主要是根据其蛋白质特性（Decker, McKenzie, McGuckin, and Slocumb, 1959； Schur和Sandson, 1963; Schmid, 1964），除了类风湿因子（Krehl, Boisvert, de Forest, and Mucci, 1957）和几种酶（Ziff, Simson, Scull, Smith, Shatton, and Mainland, 1955； Jacox和Feldmahn, 1955； Smith和Hamerman， 1962）。关于特定蛋白质的定量信息很少。我们选择了在纤维蛋白形成和降解中起作用的球蛋白进行测量，因为它们是炎症液的成分，但被认为在滑液中不存在（Ropes和Bauer, 1953； Cho和Neuhaus， 1960）。当细胞产物存在时，激活可能产生或破坏纤维蛋白（Seegers, 1962; Barnhart, 1963; Purcell and Barnhart, 1963）。
The significance of extravascular coagulation and fibrinolysis is poorly understood and little appre-ciated. A unique opportunityfor studying these events is provided in arthritis where the joint fluids may reflect the presence and extent of inflammation. This report on 144 pathological fluids expands our knowledge of the biochemistry of inflammation. Further, it may provide a more instructive base than currently available for comprehending the mechanisms operative in arthritis. Fibrin deposition must be considered seriously as a contributor to permanent joint damage.Synovial fluid isa complex mixture of substances largely derived from the plasma but also the product and recipient of both cells in the synovial membrane and extravascular leucocytes (Ropes and Bauer, 1953). Protein comprises 1* 4 to 5* 6 per cent. of the synovial fluid and is mainly knownin terms of electrophoretic properties (Decker, McKenzie, McGuckin, and Slocumb, 1959; Schur and Sandson, 1963; Schmid, 1964) except for rheumatoid factor (Krehl, Boisvert, de Forest, and Mucci, 1957) and several enzymes (Ziff, Simson, Scull, Smith, Shatton, and Mainland, 1955; Jacox and Feldmahn, 1955; Smith and Hamerman, 1962). There is little quantitative information on specific proteins. We selected globulins that function in fibrin formation and degradation for measurement as they are constituents of inflammation fluids but are considered absent in synovial fluid (Ropes and Bauer, 1953; Cho and Neuhaus, 1960). When present with cellular products, activation may occur to yield or destroy fibrin (Seegers, 1962; Barnhart, 1963; Purcell and Barnhart, 1963).