Long-term tidal liquid ventilation in premature lambs: Physiologic, biochemical and histological correlates
Long-term tidal liquid ventilation in premature lambs: Physiologic, biochemical and histological correlates
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DOI：
10.1159/000072307
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Shaffer, TH
中科院分区：
文献类型：
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作者：
Cox, C;Stavis, RL;Shaffer, TH
婴儿慢性肺病仍然是个问题。潮式液体通气 (TLV) 可改善肺力学并提供有效的气体交换。我们假设 TLV 可以安全地支持早产羔羊，并评估了 9 只早产羔羊（妊娠 132 天）的 TLV 长达 72 小时。结果（平均值 +/- SEM）：pH 7.36 +/- 0.003，Pa-CO2 44 +/- 0.34 mm Hg，Pa-O2 170 +/- 4.8 mm Hg，顺应性 = 1.65 +/- 0.24 ml/cm H2O/kg，平均动脉压 = 53 +/- 0.08 mm Hg，心率 = 189 +/- 1.5节拍数。 24 小时内血液 perflubron 水平为 6.0 +/- 0.24 mug/ml。组织 perflubron 水平从 24 小时时的 81 +/- 7.0 mug/g 增加到 72 小时时的 108 +/- 15 mug/g (p < 0.05)。作为组织函数的 perflubron 浓度存在差异 (p < 0.001)，与脂质水平相关 (r(2) = 0.93，p < 0.01)。这些数据表明，TLV 在 72 小时内对早产羔羊来说既安全又有效。版权所有 (C) 2003 S. Karger AG，巴塞尔。
Chronic lung disease in infants continues to be problematic. Tidal liquid ventilation (TLV) improves lung mechanics and provides effective gas exchange. We hypothesized that premature lambs could be supported safely with TLV and evaluated 9 preterm lambs (132 days gestation) on TLV up to 72 h. Results (mean +/- SEM): pH 7.36 +/- 0.003, Pa-CO2 44 +/- 0.34 mm Hg, Pa-O2 170 +/- 4.8 mm Hg, compliance = 1.65 +/- 0.24 ml/cm H2O/kg, mean arterial blood pressure = 53 +/- 0.08 mm Hg, heart rate = 189 +/- 1.5 bpm. Blood perflubron levels were 6.0 +/- 0.24 mug/ml over 24 h. Tissue perflubron levels increased from 81 +/- 7.0 mug/g at 24 h to 108 +/- 15 mug/g at 72 h (p < 0.05). There was a difference in perflubron concentrations as a function of tissue (p < 0.001) that correlated to lipid levels (r(2) = 0.93, p < 0.01). These data demonstrate that TLV is both safe and effective up to 72 h in premature lambs. Copyright (C) 2003 S. Karger AG, Basel.