Alterations in upper limb muscle synergy structure in chronic stroke survivors
Alterations in upper limb muscle synergy structure in chronic stroke survivors
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DOI：
10.1152/jn.00670.2012
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发表时间：
2013-02-01
影响因子：
2.5
通讯作者：
Beer, Randall F.
中科院分区：
文献类型：
--
作者：
Roh, Jinsook;Rymer, William Z.;Beer, Randall F.
Roh J，Rymer WZ，Perreault EJ，Yoo SB，Beer RF.慢性中风幸存者上肢肌肉协同结构的改变。J Neurophysiol 109：768-781，2013.首次发表于2012年11月14日; doi：10.1152/jn.00670.2012.-以前在神经系统完整的受试者中进行的研究表明，运动协调可以通过几种肌肉协同作用的任务依赖性组合来描述，这里定义为一组肌肉的固定激活模式。严重受损的中风幸存者的手臂功能的特点是刻板的姿势和运动模式，涉及肩和肘。因此，我们假设，肌肉协同组成改变严重受损中风幸存者。使用等长肌力匹配方案，我们检查了10名中风幸存者（Fugl-Meyer < 25/66）患臂和6名年龄匹配对照者双臂肘和肩部肌肉的空间激活模式。使用非负矩阵分解确定潜在的肌肉协同作用。在两组中，肌肉激活模式可以通过几个肌肉协同作用（通常为4个）的组合来重建。我们没有发现异常耦合的肩肘肌肉在个别肌肉协同作用。在中风幸存者中，与对照组一样，两种协同作用由手肘屈肌和伸肌的单独激活组成。然而，涉及近端肌肉的肌肉协同作用在中风后表现出一致的变化。与对照组不同，前三角肌与肩外展肌/伸肌协同作用中的内侧和后三角肌共同激活，卒中中肩内收肌/屈肌协同作用主要由胸大肌激活，前三角肌激活有限。招募改变肩部肌肉协同作用与异常的任务表现密切相关。总的来说，我们的研究结果表明，一个受损的控制个人三角肌头可能有助于中风后手臂功能的缺陷。
Roh J, Rymer WZ, Perreault EJ, Yoo SB, Beer RF. Alterations in upper limb muscle synergy structure in chronic stroke survivors. J Neurophysiol 109: 768-781, 2013. First published November 14, 2012; doi:10.1152/jn.00670.2012.-Previous studies in neurologically intact subjects have shown that motor coordination can be described by task-dependent combinations of a few muscle synergies, defined here as a fixed pattern of activation across a set of muscles. Arm function in severely impaired stroke survivors is characterized by stereotypical postural and movement patterns involving the shoulder and elbow. Accordingly, we hypothesized that muscle synergy composition is altered in severely impaired stroke survivors. Using an isometric force matching protocol, we examined the spatial activation patterns of elbow and shoulder muscles in the affected arm of 10 stroke survivors (Fugl-Meyer < 25/66) and in both arms of six age-matched controls. Underlying muscle synergies were identified using non-negative matrix factorization. In both groups, muscle activation patterns could be reconstructed by combinations of a few muscle synergies (typically 4). We did not find abnormal coupling of shoulder and elbow muscles within individual muscle synergies. In stroke survivors, as in controls, two of the synergies were comprised of isolated activation of the elbow flexors and extensors. However, muscle synergies involving proximal muscles exhibited consistent alterations following stroke. Unlike controls, the anterior deltoid was coactivated with medial and posterior deltoids within the shoulder abductor/extensor synergy and the shoulder adductor/flexor synergy in stroke was dominated by activation of pectoralis major, with limited anterior deltoid activation. Recruitment of the altered shoulder muscle synergies was strongly associated with abnormal task performance. Overall, our results suggest that an impaired control of the individual deltoid heads may contribute to poststroke deficits in arm function.