Analysis of driven nanorod transport through a biopolymer matrix
Analysis of driven nanorod transport through a biopolymer matrix
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DOI：
10.1016/j.jmmm.2014.09.059
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发表时间：
2015-04-15
影响因子：
2.7
通讯作者：
Superfine, Richard
中科院分区：
文献类型：
--
作者：
Mair, Lamar O.;Weinberg, Irving N.;Superfine, Richard
已提出应用磁场来引导和保留体内载药磁性颗粒作为治疗疾病的一种方法。在很大程度上，这些努力都是针对肿瘤的。肿瘤内长距离运输的一个重要障碍是细胞外基质（ECM）。我们通过 ECM 对经历磁泳的 18 nm 直径纳米棒进行单粒子测量，并分析这些纳米棒的二维运动。我们在这种粘弹性环境中观察颗粒内磁泳，并测量这些纳米棒有效受阻与有效平移的时间比例。 (C) 2014 Elsevier B.V. 保留所有权利，
Applying magnetic fields to guide and retain drug-loaded magnetic particles in vivo has been proposed as a way of treating illnesses. Largely, these efforts have been targeted at tumors. One significant barrier to long range transport within tumors is the extracellular matrix (ECM). We perform single particle measurements of 18 nm diameter nanorods undergoing magnetophoresis through ECM, and analyze the motion of these nanorods in two dimensions. We observe intra-particle magnetophoresis in this viscoelastic environment and measure the fraction of time these nanorods spend effectively hindered, versus effectively translating. (C) 2014 Elsevier B.V. All rights reserved,