Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors.
Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors.
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双侧睾丸生殖细胞肿瘤男性第一和第二原发性恶性肿瘤的组织学之间无关联。
DOI：
10.1093/aje/kwt100
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发表时间：
2013
影响因子：
5
通讯作者：
Cortessis,VictoriaK
中科院分区：
文献类型：
--
作者：
Thomas,JenniferPhayJohnson;Davis-Dao,Carol;Lewinger,JuanPablo;Siegmund,KimberlyD;Hamilton,AnnS;Daneshmand,Siamak;Skinner,EilaC;Thomas,DuncanC;Cortessis,VictoriaK
睾丸生殖细胞肿瘤（tgct）是年轻男性最常见的肿瘤，组织学上分为精原细胞瘤或非精原细胞瘤/混合生殖细胞肿瘤。这些亚型因诊断时的年龄和临床病程而异，但对病因的区别知之甚少。为了验证组织学亚型具有不同的未被识别的病因的假设，我们使用了最近描述的方法，估计患有2个原发性tgct的男性的第一个和第二个肿瘤的组织学类型之间的关系。在1972年至2006年期间，通过美国基于人群的癌症登记处确定了488名患有2例原发性tgct的男性研究人群。单因素logistic回归分析显示，第二次原发性tgct的组织学与第一次原发性tgct的组织学相关（优势比= 1.70,95%可信区间：1.14,2.52）；然而，在对首次TGCT诊断年龄进行调整后的分析中，这种关联并不存在（优势比= 1.09,95%可信区间：0.71,1.70）。如果这些亚型具有相同的病因，但在诊断时的进展速度不同，或者tgct的组织学命运受到年龄相关过程的影响，则可以预期这些结果。有2个原发性tgct的男性提供了新的机会来了解组织学亚型是否可能具有相同的病因，因此结果可能为旨在确定病因的研究提供信息。
Testicular germ cell tumors (TGCTs), the most common neoplasms of young men, are categorized histologically as either seminomas or nonseminomas/mixed germ cell tumors. These subtypes differ by age at diagnosis and clinical course, but little is known about etiological distinctions. To test the hypothesis that histological subtypes have distinct sets of unrecognized etiological factors, we used a recently described approach, estimating the association between histological types of first and second tumors of men with 2 primary TGCTs. The study population of 488 men each with 2 primary TGCTs was ascertained through population-based cancer registries in the United States between 1972 and 2006. Univariate logistic regression analysis revealed that the histology of second primary TGCTs was associated with the histology of first TGCTs (odds ratio = 1.70, 95% confidence interval: 1.14, 2.52); however, the association did not persist in analyses adjusted for age at diagnosis of first TGCT (odds ratio = 1.09, 95% confidence interval: 0.71, 1.70). These results would be expected if the subtypes share etiology but experience different rates of progression to diagnosis or if the histological fate of TGCTs is influenced by age-related processes. Men with 2 primary TGCTs provide novel opportunities to learn whether histological subtypes are likely to share etiology, so results may inform research designed to identify causes.