Increased cortical oxidative metabolism due to sensory stimulation: Implications for functional brain imaging
Increased cortical oxidative metabolism due to sensory stimulation: Implications for functional brain imaging
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DOI：
10.1126/science.286.5444.1555
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发表时间：
1999-11-19
期刊：
影响因子：
56.9
通讯作者：
Grinvald, A
中科院分区：
文献类型：
--
作者：
Vanzetta, I;Grinvald, A
现代功能性大脑绘图依赖于神经元电活动与皮质微循环的相互作用。高度局部化、刺激引起的初始脱氧是否存在仍然存在争议。在这里，使用外源指示剂的氧依赖性磷光猝灭直接测量微循环中活动依赖性氧张力的变化。感觉刺激后的第一个事件是耗氧量增加，随后是血流量增加。由于耗氧量和神经元活动是共定位的，但延迟血流不是共定位的，因此专注于该初始阶段的功能磁共振成像将产生更高的空间分辨率，最终实现人脑基本处理模块的无创可视化。
Modern functional brain mapping relies on interactions of neuronal electrical activity with the cortical microcirculation. The existence of a highly localized, stimulus-evoked initial deoxygenation has remained a controversy. Here, the activity-dependent oxygen tension changes in the microcirculation were measured directly, using oxygen-dependent phosphorescence quenching of an exogenous indicator. The first event after sensory stimulation was an increase in oxygen consumption, followed by an increase in blood flow. Because oxygen consumption and neuronal activity are colocalized but the delayed blood flow is not, functional magnetic resonance imaging focused on this initial phase will yield much higher spatial resolution, ultimately enabling the noninvasive visualization of fundamental processing modules in the human brain.