Gene by environment interaction:: The-159C/T polymorphism in the promoter region of the CD14 gene modifies the effect of alcohol consumption on serum IgE levels
Gene by environment interaction:: The-159C/T polymorphism in the promoter region of the CD14 gene modifies the effect of alcohol consumption on serum IgE levels
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DOI：
10.1111/j.1530-0277.2006.00007.x
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Gonzalez-Quintela, A
中科院分区：
文献类型：
--
作者：
Campos, J;Gude, F;Gonzalez-Quintela, A
背景：酗酒者血清IgE升高。与大量饮酒相关的大部分免疫变化都是由内毒素介导的。目的：探讨饮酒与CD14基因启动子区-159C/T多态与血清IgE水平的关系。目的：探讨饮酒与CD14基因启动子区-159C/T多态与血清IgE水平之间的交互作用。共有140人戒酒，112人中度饮酒(1-280克/周)，163人重度饮酒(>；280克/周)。主要检测方法包括CD14/-159C/T基因型、一组皮肤点刺试验、血清总IgE和抗常见空气变应原特异性IgE(Phadiatop试验)。结果：大量饮酒与血清总IgE值升高和常见空气变应原特异性IgE阳性有关，但CD14/-159c等位基因携带者(CC纯合子或CT杂合子)的相关性强于CD14/-159TT纯合子。在调整潜在混杂因素后，大量饮酒与CD14/-159c等位基因的血清总IgE值和特异性IgE值的加法和乘法交互作用仍然存在。结论：CD14/-159C/T基因多态性改变了饮酒对血清IgE水平的影响。
Background: Serum IgE is increased in heavy drinkers. Endotoxin mediates most of the immunological alterations associated with heavy drinking. The -159C/T polymorphism in the promoter region of the gene encoding CD14 (an endotoxin receptor) is associated with serum IgE levels in different populations.Aim: To investigate the possible interaction between alcohol intake and the -159C/T polymorphism in the promoter region of the CD14 gene for serum IgE levels.Methods: A total of 415 individuals (51.6% males, median age 50 years, range 18-92 years) were studied. A total of 140 individuals were alcohol abstainers, 112 were moderate drinkers (1-280 g/week), and 163 were heavy drinkers (> 280 g/week). Main determinations included the CD14/-159C/T genotype, a panel of skin prick tests, total serum IgE, and specific serum IgE against common aeroallergens (Phadiatop test).Results: Heavy drinking was associated with increased total serum IgE values and with positive specific serum IgE to common aeroallergens, but the association was stronger in carriers of the CD14/ -159C allele (either CC homozygotes or CT heterozygotes) than in CD14/-159TT homozygotes. Both additive and multiplicative interactions between heavy drinking and the CD14/-159C allele for total and specific serum IgE values was still present after adjusting for potential confounders. Neither alcohol consumption nor the CD14/-159 genotype was associated with skin prick test positivity.Conclusions: The CD14/-159C/T polymorphisin modifies the effect of alcohol consumption on serum IgE levels.