Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk.
Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk.
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发表时间：
1997-03
期刊：
影响因子：
11.2
通讯作者：
J. Stanford;J. Just;M. Gibbs;K. Wicklund;C. Neal;B. Blumenstein;E. Ostrander
中科院分区：
文献类型：
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作者：
J. Stanford;J. Just;M. Gibbs;K. Wicklund;C. Neal;B. Blumenstein;E. Ostrander
我们分析了雄激素受体基因内多态性（CAG）n和（GGN）n区域，这些区域来自一项基于人群的中年（40-64岁）白人男性前列腺癌病例对照研究的参与者。重复长度与前列腺癌风险之间的关联以及混杂和修饰因素（如年龄、前列腺癌家族史和体重指数）的影响进行了评估。DNA可用于301例病例和277例对照。与CAG重复次数相关的前列腺癌的总体年龄调整相对比值为0.97 [95%置信区间（CI），0.92-1.03]，表明每增加一次CAG重复，前列腺癌的风险降低3%。进一步的分析确定了几个风险增加的亚组。这些人的CAG重复次数少于中位数（16次重复）。总的来说，那些有或= 22; GGN，> 16）的男性。这些数据表明，生殖系DNA内雄激素受体重复序列的测定可能有助于评估个体患前列腺癌的风险。
We analyzed the polymorphic (CAG)n and (GGN)n regions within the androgen receptor gene from participants in a population-based case-control study of prostate cancer in middle-aged (40-64 years) Caucasian men. The associations between repeat lengths and risk of prostate cancer and the effects of confounding and modifying factors, such as age, family history of prostate cancer, and body mass index, were evaluated. DNA was available for 301 cases and 277 controls. The overall age-adjusted relative odds of prostate cancer associated with the number of (CAG) repeats as a continuous variable was 0.97 [95% confidence interval (CI), 0.92-1.03], suggesting a 3% decrease in risk of prostate cancer for each additional (CAG) repeat. Further analyses identified several subgroups at increased risk. These were men with less than the median number of CAG repeats ( 16 repeats. Overall, those men who had or = 22; GGN, > 16). These data suggest that determination of both androgen receptor repeats within germ-line DNA may be useful in assessing an individual's risk of developing prostate cancer.