Pathophysiology of obesity-associated type II diabetes (NIDDM): implications from longitudinal studies of non-human primates.
Pathophysiology of obesity-associated type II diabetes (NIDDM): implications from longitudinal studies of non-human primates.
复制标题
作者：
Barbara C. Hansen
对成人发病的II型非胰岛素依赖型糖尿病患者的临床观察通常支持这种疾病存在很大程度的异质性的观点。然而，对同卵双胞胎的研究显示出如此高的一致性，以至于在大多数情况下，对多种病因和多种疾病的想法提出了质疑。这些研究表明，寻求一个统一的假说的基础上的II型糖尿病的重要性。对恒河猴（Macaca mulatta）的前瞻性纵向研究现在提供了这种综合情况，并表明疾病进展速度和表达时间的异质性，其发展模式或导致明显糖尿病的事件顺序很少或没有异质性。
Clinical observations of humans who have developed adult-onset Type II, non-insulin dependent diabetes have generally supported the idea that there is a large degree of heterogeneity in this disease. Studies of monozygotic twins, however, show such a high degree of concordance as to make doubtful the idea of multiple causes and multiple disease in most instances. Such studies suggest the importance of seeking a unified hypothesis for the basis of Type II diabetes. Prospective longitudinal studies of rhesus monkeys (Macaca mulatta) now provide that integrated picture, and suggest heterogeneity in rate of progression and timing of expression of the disease, with little or no heterogeneity in its pattern of development or in the sequence of events leading to overt diabetes.