Microbial Sensory Rhodopsins: Photochemistry and Function
Microbial Sensory Rhodopsins: Photochemistry and Function
复制标题
微生物感觉视紫红质：光化学和功能
DOI：
--
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
R. Bogomolni
中科院分区：
文献类型：
--
作者：
J. Spudich;D. Zacks;R. Bogomolni
本文综述了微生物感觉视紫红质、视色素样视黄嘌呤光感受器的研究进展，这些光感受器在古细菌（如盐盐菌）和单细胞真核藻类（如莱茵衣藻）中起着趋光作用。在嗜盐古菌中已知六种明显不同的感觉视紫红质。最具特征的是感觉视紫红质I (SR-I)，一种颜色敏感受体，将吸引和排斥光信号传递给紧密结合的传感器蛋白HtrI（盐细菌的感觉视紫红质I传感器）。从分子生物学和生物物理学的角度综述了SR-I/HtrI复合物信号转导机制的新进展。讨论了HtrI对受体中光诱导质子转移的影响及其在信号传导中的可能作用。目前有关相关古菌感觉视紫红质家族的知识被提出。
The review covers recent progress on microbial sensory rhodopsins, visual pigment-like retinylidene photoreceptors that function in phototaxis by archaeons, such as Halobacterium salinarium, and by unicellular eukaryotic algae, such as Chlamydomonas reinhardtii. Six demonstrably different sensory rhodopsins are known in halophilic archaea. The best characterized is sensory rhodopsin I (SR-I), a color-sensitive receptor that relays attractant and repellent photosignals to a tightly bound transducer protein HtrI (halobacterial transducer for sensory rhodopsin I). New advances in the mechanism of signal transduction by the SR-I/HtrI complex from molecular-biological and biophysical approaches are summarized. Effects of HtrI on light-induced proton transfers in the receptor are discussed for their possible role in signaling. Current knowledge concerning the growing family of related archaeal sensory rhodopsins is presented.
The evidence for a sensory rhodopsin in phototaxis by C. reinhardtii and other unicellular eukaryotic algae is reviewed. The molecular information is more limited than for the archaeal organisms, but the physiological information is rich and complex. Compelling data exist for a single retinal-containing receptor mediating both phototaxis and photophobic responses in C. reinhardtii. From retinal analog studies, the isomeric configuration and ring/chain conformation of the retinal in the receptor appear to be identical to those of the archaeal sensory rhodopsins. Also, photoisomerization from all-trans- to 13-cis-retinal appears to be the trigger for signaling, as in the archaeal pigments. Conflicting early studies suggesting an 11-cis-retinal chromophore and signaling without photoisomerization are analyzed and possible explanations for those reports are suggested.
As a general conclusion, the microbial sensory rhodopsins provide an opportunity to explore photochemistry and protein/protein interaction in photosensory transduction in genetically tractable organisms.
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影响因子：
2.9
作者：
Yan,B;Takahashi,T;Johnson,R;Spudich,JL
通讯作者：
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DNA 杂交揭示视觉色素同源性。
DOI：
10.1126/science.3010467
发表时间：
1986
期刊：
Science (New York, N.Y.)
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作者：
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通讯作者：
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DOI：
10.1073/pnas.88.21.9412
发表时间：
1991-11
影响因子：
11.1
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通讯作者：
B. Yan;K. Nakanishi;J. Spudich
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DOI：
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发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
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DOI：
10.1073/pnas.85.17.6379
发表时间：
1988
影响因子：
11.1
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Foster,KW;Saranak,J;Zarrilli,G
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Zarrilli,G