Avian influenza virus
Avian influenza virus
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DOI：
10.1016/j.cimid.2008.01.007
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发表时间：
2009-07-01
影响因子：
2
通讯作者：
Saif, Yehia A.
中科院分区：
文献类型：
--
作者：
Lee, Chang-Won;Saif, Yehia A.
禽流感病毒通常不会在人类中有效复制，这表明禽流感病毒不太可能直接传播给人类。然而，自1997年以来，已经确定了几例人感染不同亚型（H5N1、H7N7和H9N2）禽流感病毒的病例，并提高了禽流感病毒在人类中大流行的可能性。虽然存在人传人的间接证据，但从人身上分离的新型禽源流感病毒缺乏有效地在人与人之间传播的能力。然而，人类感染禽源H5N1病毒的持续存在增加了产生具有大流行潜力的人类适应性禽流感病毒的可能性。因此，更好地了解流感病毒宿主限制的生物学和遗传学基础是确定将新型流感病毒引入人群是否会导致大流行的关键因素。在这篇文章中，我们回顾了A型流感病毒，其中所有禽流感病毒的分类目前的知识。(C)2008爱思唯尔有限公司版权所有。
Avian influenza viruses do not typically replicate efficiently in humans, indicating direct transmission of avian influenza virus to humans is unlikely. However, since 1997, several cases of human infections with different subtypes (H5N1, H7N7, and H9N2) of avian influenza viruses have been identified and raised the pandemic potential of avian influenza virus in humans. Although circumstantial evidence of human to human transmission exists, the novel avian-origin influenza viruses isolated from humans lack the abililty to transmit efficiently from person-to-person. However, the on-going human infection with avian-origin H5N1 viruses increases the likelihood of the generation of human-adapted avian influenza virus with pandemic potential. Thus, a better understanding of the biological and genetic basis of host restriction of influenza viruses is a critical factor in determining whether the introduction of a novel influenza virus into the human population will result in a pandemic. In this article, we review current knowledge of type A influenza virus in which all avian influenza viruses are categorized. (C) 2008 Elsevier Ltd. All rights reserved.