Carotid bodies and ventilatory control dynamics in man.
Carotid bodies and ventilatory control dynamics in man.
复制标题
人体颈动脉体和通气控制动力学。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
K. Wasserman
中科院分区：
文献类型：
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作者：
B. Whipp;K. Wasserman
通过比较一组对照组受试者对以下几种反应的反应：a)低氧-高氧转换，b)稳态高碳酸血症，c)恒定负荷和递增运动，以及d)在不同氧气水平下屏气的反应，与手术切除(CBR)的受试者的反应进行比较，从而推断出颈动脉小体在人类呼吸动力学中的正常作用。计算呼吸量、代谢率和肺泡气体压力，并从臂动脉导管采集血样。对于尤卡尼亚患者，无论是在静息状态下还是在运动过程中，低氧的呼吸动力都完全由颈动脉小体提供，而在真氧状态下，只有大约相当于30%的血压反应可归因于这些结构。CBR导致运动时呼吸动力学明显减慢，导致一过性呼吸性酸中毒。在适度运动的稳定状态下，CBR组的通气量是正常的，因为其他受体提供了大约相当于颈动脉小体15%的动力。运动引起的急性代谢性酸中毒的呼吸代偿似乎完全由颈动脉小体介导。CBR后屏气时间显著延长，特别是在低氧条件下。因此，颈动脉小体为人类的呼吸控制提供了重要信息，尤其是在缺氧、代谢性酸中毒和肌肉运动的动态状态下。
The normal role of the carotid bodies in ventilatory dynamics in man has been inferred from studies comparing the responses of a group of control subjects to: a) hypoxic-hyperoxic transitions, b) steady-state hypercapnia, c) constant-load and incremental exercise, and d) breath holding with various inspired O2 levels, with the responses of subjects who had had both carotid bodies surgically resected (CBR). Ventilation, metabolic rate, and alveolar gas tensions were computed breath by breath and blood was sampled from a brachial artery catheter. With eucapnia, hypoxic ventilatory drive is subserved entirely by the carotid bodies, both at rest and during exercise, whereas only approximatly equal to 30% of the hyercapnic response in euoxia is attributable to these structures. CBR resulted in appreciable slowing of the ventilatory dynamics during exercise, causing a transient respiratory acidosis. In the steady state of moderate exercise, ventilation was normal in the CBR group, as other receptors provide the approximately equal to 15% of the drive attributable to the carotid bodies. The respiratory compensation for the acute metabolic acidosis of exercise appears to be exclusively mediated by the carotid bodies. Breath-holding time is significantly prolonged following CBR, especially under hypoxic conditions. The carotid bodies therefore provide important information to respiratory control in man, most notably under hypoxia, metabolic acidosis, and dynamic states of muscular exercise.