Identification of nasal bacterial flora profile and carriage rates of methicillin-resistant Staphylococcus aureus in patients with allergic rhinitis
Identification of nasal bacterial flora profile and carriage rates of methicillin-resistant Staphylococcus aureus in patients with allergic rhinitis
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DOI：
10.1007/s00405-013-2492-2
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发表时间：
2014-01-01
影响因子：
2.6
通讯作者：
Akbay, Ercan
中科院分区：
文献类型：
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作者：
Cevik, Cengiz;Yula, Erkan;Akbay, Ercan
本研究的目的是评估与健康个体相比，过敏性鼻炎（AR）对鼻腔菌群和耐药微生物定植率的影响。这种定植对于 AR 相关疾病、耐药微生物的携带及其并发症和共病可能很重要。该研究分两组进行。研究组由 54 名成年 AR 患者组成。对照组由50名健康个体组成。两组患者在过去一个月内均未使用过任何抗生素、局部或全身类固醇。采用拭子鼻涂片常规方法评估鼻腔细菌菌群组成和耐甲氧西林金黄色葡萄球菌（MRSA）携带率。在研究组中，甲氧西林敏感凝固酶阴性葡萄球菌（MRCNS）检出率为30%；检测到类白喉菌占 25%，耐甲氧西林凝固酶阴性葡萄球菌占 13%，耐甲氧西林金黄色葡萄球菌占 9%，耐甲氧西林金黄色葡萄球菌占 3.7%，超广谱 β 内酰胺酶革兰氏阴性杆菌 (GR-ESBL+) 占 3.7%。对照组中，54%检出甲氧西林敏感凝固酶阴性葡萄球菌；检测到类白喉菌占 21%，耐甲氧西林凝固酶阴性葡萄球菌占 1.5%，耐甲氧西林金黄色葡萄球菌占 16%，耐甲氧西林金黄色葡萄球菌占 1.5%，Gr-ESBL(-) 占 4%，草绿色链球菌占 3%。研究发现，AR 患者的 MRSA 和 MRCNS 定植率较高。与健康受试者相比，这种定植对于 AR 相关疾病、耐药微生物的携带及其并发症和共病可能很重要。
The aim of the present study was to evaluate the effect of allergic rhinitis (AR) on the nasal flora and colonization rates of resistant microorganisms in comparison to healthy individuals. This colonization may be important in terms of AR-related disorders, the resistant microorganisms' carriage, and its complications and co-morbidities. The study was performed with two groups. The study group was composed of 54 adult patients with AR. The control group was composed of 50 healthy individuals. None of the individuals in both groups have used any antibiotics, local or systemic steroid within the last month. Composition of bacterial nasal flora and carriage rates of methicillin-resistant Staphylococcus aureus (MRSA) were evaluated with conventional methods by taking nasal smears with a swab. In the study group, methicillin-sensitive coagulase-negative staphylococci (MRCNS) were detected in 30 %; whereas diphtheroids in 25 %, methicillin-resistant coagulase-negative staphylococci in 13 %, methicillin-sensitive S. aureus in 9 %, methicillin-resistant S. aureus in 3.7 %, and extended-spectrum beta lactamases-positive gram-negative bacilli (GR-ESBL+) in 3.7 % were detected. In the control group, methicillin-sensitive coagulase-negative staphylococci were detected in 54 %; whereas diphtheroids in 21 %, methicillin-resistant coagulase-negative staphylococci in 1.5 %, methicillin-sensitive S. aureus in 16 %, methicillin-resistant S. aureus in 1.5 %, Gr-ESBL(-) in 4 %, and viridians streptococci in 3 % were detected. It is found that the MRSA and MRCNS colonization is higher in patients with AR. This colonization may be important in terms of AR-related disorders, the resistant microorganisms' carriage, and its complications and co-morbidities in comparison to healthy subjects.