Sudoscan is an effective screening method for asymptomatic diabetic neuropathy in Chinese type 2 diabetes mellitus patients.
Sudoscan is an effective screening method for asymptomatic diabetic neuropathy in Chinese type 2 diabetes mellitus patients.
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Sudoscan是中国2型糖尿病患者无症状糖尿病神经病变的有效筛查方法。
DOI：
10.1111/jdi.12575
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发表时间：
2017-05
影响因子：
3.2
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Mao F;Liu S;Qiao X;Zheng H;Xiong Q;Wen J;Liu L;Tang M;Zhang S;Zhang Z;Ye H;Lu B;Li Y
本研究的目的是使用促汗功能测试 Sudoscan 作为评估中国 2 型糖尿病患者无症状糖尿病远端对称性多发性神经病的筛查方法。因此，可以更多地关注那些在日常临床中容易被忽视和漏诊的无症状患者。共有 394 名中国 2 型糖尿病患者入组，并使用神经症状评分、神经病变残疾评分和振动感知阈值测试神经病变的症状和临床体征。进行Sudoscan，收集结果作为手和脚的电化学皮肤电导的测量。在本研究中，我们发现无症状神经病变患者的Sudoscan结果异常率高于无神经病变患者和有症状神经病变患者。这项研究还表明，足部较低的电化学皮肤电导与症状、神经症状评分（r = -0.124，P < 0.05）、神经病变残疾评分（r = -0.3，P < 0.01）和振动感知阈值（r = -0.18，P < 0.05）的增加显着相关。 Logistic 分析显示，年龄（比值比 1.042，95% 置信区间 1.014−1.071，P < 0.05）和足部电化学皮肤电导水平（比值比 0.98，95% 置信区间 0.962–0.993，P < 0.01）与糖尿病远端对称性多发性神经病独立相关。 Sudoscan 可能是筛查中国 2 型糖尿病患者无症状糖尿病远端对称性多发性神经病的有前途的工具。
The aim of the present study was to use the sudomotor function test, Sudoscan, as a screening method for the evaluation of asymptomatic diabetic distal symmetric polyneuropathy in Chinese type 2 diabetes patients. As a result, more attention could be paid to those asymptomatic patients who could be easily neglected and underdiagnosed in everyday clinic. A total of 394 Chinese type 2 diabetes patients were enrolled and tested for symptoms and clinical signs of neuropathy using the Neurological Symptom Score, Neuropathy Disability Score, and vibration perception threshold. Sudoscan was carried out, and the results were collected as the measurement of the electrochemical skin conductance of both hands and feet. In the present study, we found that the abnormal rate of Sudoscan results in patients with asymptomatic neuropathy was higher than those without neuropathy and those with symptomatic neuropathy. This study also showed that lower electrochemical skin conductance at the feet was significantly associated with increasing symptoms, Neurological Symptom Score (r = −0.124, P < 0.05), Neuropathy Disability Score (r = −0.3, P < 0.01) and vibration perception threshold value (r = −0.18, P < 0.05). Logistic analysis showed that age (odds ratio 1.042, 95% confidence interval 1.014−1.071, P < 0.05) and feet electrochemical skin conductance levels (odds ratio 0.98, 95% confidence interval 0.962–0.993, P < 0.01) were independently associated with diabetic distal symmetric polyneuropathy. Sudoscan might be a promising tool to screen asymptomatic diabetic distal symmetric polyneuropathy in Chinese patients with type 2 diabetes mellitus.