Double dissociation of N1 and P3 abnormalities in deficit and nondeficit schizophrenia
Double dissociation of N1 and P3 abnormalities in deficit and nondeficit schizophrenia
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DOI：
10.1016/j.schres.2007.01.026
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发表时间：
2007-05-01
影响因子：
4.5
通讯作者：
Maj, Mario
中科院分区：
文献类型：
--
作者：
Mucci, Armida;Galderisi, Silvana;Maj, Mario
有人提出，持久的特发性阴性症状的存在定义了一组患有与其他形式的精神分裂症（非缺陷型精神分裂症，NDS）不同的疾病（缺陷型精神分裂症，DS）的患者。尽管多项研究结果支持这一假设，但仍不能排除 DS 代表单一精神分裂症连续体严重终结的可能性。我们测试了 DS 和 NDS 相对于事件相关电位 (ERIs) 不同的假设。在临床稳定的 DS 和 NDS 门诊患者以及匹配的健康受试者 (HCS) 中评估了 ERP 成分的幅度、头皮地形和皮质来源。每组招募20名受试者。在完成目标检测任务的受试者中，准确率没有组间差异。对于 N1，与 HCS 相比，只有 DS 患者表现出头皮中央引线振幅降低以及扣带回和海马旁回电流源密度降低。对于 P3，与 HCS 相比，只有 NDS 患者表现出左后区域的单侧振幅降低，以及左颞叶和双侧额叶、扣带回和顶叶区域的电流源密度降低。 DS 和 NDS 组在 N1 波幅和地形以及 P3 波幅和皮质源方面存在显着差异。N1 在 DS 中受到影响，但在 NDS 患者中不受影响，而 P3 仅在 NDS 中受到影响。这种双重解离与 DS 代表精神分裂症中的一个单独的疾病实体的假设是一致的。 (c) 2007 Elsevier B.V. 保留所有权利。
It has been proposed that the presence of enduring, idiopathic negative symptoms define a group of patients with a disease (deficit schizophrenia, DS) that is separate from other forms of schizophrenia (nondeficit schizophrenia, NDS). Although several findings support this hypothesis, the possibility that DS represents the severe end of a single schizophrenia continuum cannot be excluded yet. We tested the hypothesis that DS and NDS differ relative to event-related potentials (ERIs).Amplitude, scalp topography and cortical sources of the ERP components were assessed in clinically stable DS and NDS outpatients and in matched healthy subjects (HCS). Twenty subjects per group were recruited.Among the subjects who completed the target detection task, there were no group difference in accuracy. For N1, only patients with DS, as compared with HCS, showed an amplitude reduction over the scalp central leads and a reduced current source density in cingulate and parahippocampal gyrus. For P3, only patients with NDS, as compared with HCS, showed a lateralized amplitude reduction over the left posterior regions and reduced current source density in left temporal and bilateral frontal, cingulate and parietal areas. The DS and NDS groups differed significantly from each other with regard to N1 amplitude and topography, as well as P3 amplitude and cortical sources.The N1 was affected in DS but not in NDS patients, whereas P3 was affected in NDS only. This double dissociation is consistent with the hypothesis that DS represents a separate disease entity within schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.