Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior
Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior
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DOI：
10.1016/j.bbr.2011.03.038
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发表时间：
2011-09-12
影响因子：
2.7
通讯作者：
Conrad, Cheryl D.
中科院分区：
文献类型：
--
作者：
Huynh, Thu N.;Krigbaum, Amanda M.;Conrad, Cheryl D.
该实验研究了性别差异和光周期的相位是否改变了慢性束缚压力对焦虑和抑郁样行为的影响。将大鼠束缚（6 h/d/21 d），进行旷场（OF）、高架十字迷宫（EFL）、强迫游泳（FST）和蔗糖偏爱（SP）实验。慢性压力增加焦虑的男性和女性在不同的任务在黑暗阶段，但不是在光明阶段。当测试在黑暗中，慢性应激减少的时间和网格交叉的中心竞技场的OF在男性，而慢性应激减少开放臂条目和时间的女性。对于OF和ESTA，焦虑指数计算证实，考虑到运动指标时，慢性压力增加焦虑的措施。对于FST和SP，慢性应激有改变两性不动指数和蔗糖偏好的趋势，但单独没有达到统计学意义。因此，为每个任务计算单独的z分数，并求和以表示抑郁样行为的组合z分数。在轻度阶段，慢性应激增加了雄性的抑郁样行为，但减少了雌性的抑郁样行为。慢性应激在黑暗阶段对抑郁样行为没有统计学显著影响，尽管慢性应激对女性抑郁样行为的影响模式在两个光周期阶段相似。结果表明，慢性束缚应激对焦虑和抑郁样行为的影响取决于任务类型，光周期的相位和个体的性别。(C)2011 Elsevier B. V.保留所有权利。
The experiment examined whether sex differences and the phase of the light cycle modified how chronic restraint stress influenced anxiety and depressive-like behavior. Rats were restrained (6 h/d/21 d) and tested on the open field (OF), elevated plus maze (EPM), forced swim test (FST), and sucrose preference (SP) test. Chronic stress increased anxiety in both males and females in different tasks during the dark phase, but not in the light phase. When tested during the dark, chronic stress decreased time and grid crossings in the center arena of the OF in males, whereas chronic stress decreased open arm entries and time in the EPM in females. For OF and EPM, an anxiety index calculation confirmed that chronic stress increased anxiety measures when taking into consideration locomotion metrics. For the FST and SP, chronic stress had a tendency to alter the immobility index and sucrose preference in both sexes, but did not reach statistical significance alone. Therefore, a separate z-score was computed for each task and summed to represent a combined z-score of depressive-like behavior. In the light phase, chronic stress increased depressive-like behavior in males, but decreased depressive-like behavior in females. Chronic stress had no statistically significant effects on depressive-like behavior in the dark phase, although the pattern of chronic stress effects on depressive-like behavior in females was similar for both light cycle phases. The results indicate that chronic restraint stress effects on anxiety and depressive-like behavior depend upon the type of task, phase of the light cycle and sex of the individual. (C) 2011 Elsevier B.V. All rights reserved.