Survey of resistance to chloroquine by Plasmodium vivax in Indonesia
Survey of resistance to chloroquine by Plasmodium vivax in Indonesia
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DOI：
10.1016/s0035-9203(96)90526-x
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发表时间：
1996-07-01
影响因子：
2.2
通讯作者：
Wignall, FS
中科院分区：
文献类型：
--
作者：
Baird, JK;Nalim, MFS;Wignall, FS
1995年2月，我们在印度尼西亚苏门答腊西北部附近的印度洋尼亚斯岛调查了间日疟原虫疟疾患者对氯喹的抗药性。受试者为21名土著男性和女性（6-50岁），感染有>40个无性血液阶段的间日疟原虫/μ l血液，具有轻微症状或根本没有症状。这些患者中的7名在第一次监督剂量的氯喹（以24小时间隔给予10 mg/kg、10 mg/kg、5 mg/kg碱的3个剂量）之前具有>100 ng/mL全血氯喹水平。给药最后一天的全血氯喹水平证实吸收正常（范围413-3248，平均值1141，因此为616 ng/mL）。在开始治疗后第0、2、4、7、11、14、18、21和28天检查血片。3名患者在第14天至第18天之间复发了无性间日疟原虫寄生虫血症，尽管复发时全血中的氯喹水平有效（大于或等于100 ng/mL）。在尼亚斯居民中，14%的感染者出现了间日疟原虫对标准氯喹治疗的耐药性。
In February 1995 we surveyed resistance to chloroquine among patients with Plasmodium vivax malaria at Nias Island, in the Indian Ocean near north-western Sumatra, Indonesa. The subjects, 21 indigenous males and females (6-50 years old) infected with >40 asexual blood stage parasites of P. vivax per mu l of blood, had mild symptoms or none at all. Seven of these patients had >100 ng/mL whole blood chloroquine levels before the first supervised dose of chloroquine (3 doses of 10 mg/kg, 10 mg/kg, 5 mg/kg of base given at 24 h intervals). Whole blood chloroquine levels on the last day of dosing confirmed normal absorption (range 413-3248, mean 1141, so 616 ng/mL). Blood films were examined on days 0, 2, 4, 7, 11, 14, 18, 21 and 28 after initiating therapy. Three patients had recurrent asexual P. vivax parasitaemias between days 14 and 18, despite effective levels of chloroquine in whole blood (greater than or equal to 100 ng/mL) at the time of recurrence. Resistance to standard chloroquine therapy by P. vivax appeared in 14% of infections among residents of Nias.