Pharmacologic comparison of the optical isomers of methadon.
Pharmacologic comparison of the optical isomers of methadon.
复制标题
美沙酮旋光异构体的药理学比较。
DOI：
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发表时间：
1948
影响因子：
3.5
通讯作者：
K. K. Chen
中科院分区：
文献类型：
--
作者：
C. C. Scott;E. Robbins;K. K. Chen
1. l -Dolophine的镇痛作用比d -异构体大得多，在大鼠中约为7.5:1，在狗中约为25:1，在人中约为50:1。
1. The analgesic action of l -Dolophine is much greater than that of the d -isomer, the order of activity being approximately 7.5:1 in rats, 25:1 in dogs, and 50:1 in man.
2. l -Dolophine produces more narcosis than the d-form in equianalgesic doses.
3. In anesthetized dogs, l -Dolophine is 25 times as depressant to respiration, but 65 times as stimulating to duodenum, as the d -isomer.
4. There is little difference in toxicity between the l- and d -isomers in mice by intravenous injection. Either optical isomer is, however, slightly less toxic than the racemic mixture.