Influence of of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance
Influence of of the separation procedure on the properties of magnetic nanoparticles: Gaining in vitro stability and T1-T2 magnetic resonance imaging performance
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DOI：
10.1016/j.jcis.2016.03.040
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发表时间：
2016-06-15
影响因子：
9.9
通讯作者：
Rivas, Jose
中科院分区：
文献类型：
--
作者：
Guldris, Noelia;Argibay, Barbara;Rivas, Jose
用革兰氏尺度的水热法合成了涂有聚丙烯酸（PAA）的超级超磁铁氧化铁纳米颗粒（USPIOS），并通过水热法合成并广泛表征。只有经过额外离心步骤的纳米颗粒显示出狭窄的尺寸分布，高聚合物覆盖范围和理想的超级磁性。除了改善物理化学特性外，这些纳米颗粒在体外具有很高的稳定性以及双重T-1-T-2性能作为对比度（CAS）用于磁共振成像（MRI），突显了附加分离步骤在获得所需特性的材料中附加分离步骤的重要性。 （c）2016 Elsevier Inc.保留所有权利。
Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) coated with polyacrylic acid (PAA) were synthesized by a hydrothermal method in gram-scale quantity and extensively characterized. Only the nanoparticles subjected to an additional centrifugation step showed narrow size distribution, high polymeric coverage, and ideal superparamagnetism. In addition to improved physico-chemical properties, these nanoparticles feature high stability in vitro as well as dual T-1-T-2 performance as contrast agents (CAs) for magnetic resonance imaging (MRI), highlighting the importance of the additional separation step in obtaining material with the desired properties. (C) 2016 Elsevier Inc. All rights reserved.