Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.
Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.
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纯合子β-地中海贫血患者脾切除术前后的血清免疫球蛋白浓度。
DOI：
10.1136/jcp.31.6.546
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发表时间：
1978
影响因子：
3.4
通讯作者：
J. Economidou
中科院分区：
文献类型：
--
作者：
M. Constantoulakis;D. Trichopoulos;O. Avgoustaki;J. Economidou
血清IgM，伊加和IgG浓度测定19例患者患有血液依赖性纯合子β地中海贫血。该研究是前瞻性的，相同的患者作为脾前切除术对照。脾切除后IgG水平迅速持续升高，IgA水平也升高，但幅度不大。在对39例脾切除和51例非脾切除患者进行一次检测的横断面研究中，发现IgM降至低水平模式。
Serum IgM, IgA, and IgG concentrations were measured in 19 patients suffering from blood-dependent homozygous beta-thalassaemia. The study was prospective and the same patients served as presplenectomy controls. IgG levels rose rapidly and continuously after splenectomy IgA levels also rose but not so sharply. IgM fell to low levelr pattern was found in the cross-sectional part of the study comprising 39 splenectomised and 51 non-splenectomised patients who were tested once.