Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala
Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala
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DOI：
10.1523/jneurosci.3432-05.2005
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发表时间：
2005-12-14
影响因子：
5.3
通讯作者：
Zahm, DS
中科院分区：
文献类型：
--
作者：
Reynolds, SM;Zahm, DS
基底前脑的功能解剖的宏系统，腹侧striatopallidum，和扩展杏仁核的神经支配的基本上同延分布的神经元在前额叶和岛叶皮层。这表明了两种不同的组织模式：会聚型，即一个特定的皮层区域只投射到这些大系统中的一个;发散型，即一个特定的皮层区域支配两个前脑大系统。为了检查潜在的组织，并可能区分这些替代品，大鼠注射两个逆行示踪剂在腹侧striatopallidum或扩展杏仁核（同型注射对）的不同部位，或与一个示踪剂在每个宏系统（异型）。前额叶和岛叶皮质的逆行标记和双重标记的神经元的重叠进行了显微镜评价。在腹侧纹状体和扩展杏仁核同型注射对产生广泛的重叠逆行标记的神经元和显着的双重标记，这表明皮质的预测广泛传播的宏系统内。与此相反，异型注射对产生显着重叠的逆行标记，但可以忽略不计的双重标记，表明腹侧striatopallidum和扩展杏仁核接收输入从单独的前额叶和岛叶皮层神经元。尾内侧壳的核caudomedial壳，一个假定的“过渡”区之间的striatopallidum和扩展杏仁核，扩展杏仁核样传入，但产生一些双标记神经元，这些只有当配对腹侧striatopallidum。这些数据表明，基底前脑的模块化组织，假设独立的信息处理的腹侧纹状体和扩展杏仁核的宏系统，反映在相应的分离的输出神经元在前额叶和岛叶皮层。
The basal forebrain functional-anatomical macrosystems, ventral striatopallidum, and extended amygdala are innervated by substantially coextensive distributions of neurons in the prefrontal and insular cortex. This suggests two alternative organizational schemes: convergent, in which a given cortical area projects exclusively to only one of these macrosystems and divergent, in which a given cortical area innervates both forebrain macrosystems. To examine the underlying organization and possibly discriminate between these alternatives, rats were injected with two retrograde tracers in different parts of ventral striatopallidum or extended amygdala ( homotypic injection pairs) or with one tracer in each macrosystem ( heterotypic). The prefrontal and insular cortex was evaluated microscopically for overlap of retrograde labeling and double labeling of neurons. Homotypic injection pairs in the ventral striatum and extended amygdala produced extensive overlap of retrogradely labeled neurons and significant double labeling, suggesting that cortical projections spread broadly within macrosystems. In contrast, heterotypic injection pairs produced significant overlap of retrograde labeling but negligible double labeling, indicating that ventral striatopallidum and extended amygdala receive inputs from separate sets of prefronto- and insular cortical neurons. The caudomedial shell of the nucleus accumbens, a supposed "transition" zone between striatopallidum and extended amygdala, had extended amygdala-like afferents but produced few double-labeled neurons and these only when paired with ventral striatopallidum. The data suggest that a modular organization of the basal forebrain, with postulated independent information processing by the ventral striatopallidal and extended amygdala macrosystems, is reflected in a corresponding segregation of output neurons in the prefrontal and insular cortices.