On botulinum neurotoxin variability.
On botulinum neurotoxin variability.
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DOI：
10.1128/mbio.02131-14
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发表时间：
2015-01-06
期刊：
影响因子：
6.4
通讯作者：
Rasotto MB
中科院分区：
文献类型：
--
作者：
Montecucco C;Rasotto MB
肉毒杆菌神经毒素序列数量的迅速增长提出了这些超强神经毒素对于产毒素梭菌属物种的变异性的可能进化意义的问题。为了进一步了解这一显着的现象，我们建议研究人员应该（一）放弃一个以人为中心的观点，这些神经毒素作为人类肉毒杆菌中毒引起剂或作为人类的治疗，（二）开始深入调查肉毒杆菌神经毒素在动物肉毒杆菌中毒在荒野中的作用，和（三）投入大量的努力，下一代测序土壤样本，以确定新的肉毒杆菌神经毒素。为了比较不同毒素的适应性，我们建议对从毒素产生到动物死亡的所有步骤进行测定。
The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric view of these neurotoxins as human botulism-causing agents or as human therapeutics, (ii) begin to investigate in depth the role of botulinum neurotoxins in animal botulism in the wilderness, and (iii) devote large efforts to next-generation sequencing of soil samples to identify novel botulinum neurotoxins. In order to compare the fitness of the different toxins, we suggest that assays of all the steps from toxin production to animal death should be performed.