Ciliary function and the role of cilia in clearance
Ciliary function and the role of cilia in clearance
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DOI：
10.1089/jam.2006.19.110
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发表时间：
2006-03-01
期刊：
影响因子：
--
通讯作者：
O'Callaghan, C
中科院分区：
文献类型：
--
作者：
Stannard, W;O'Callaghan, C
肺部和鼻腔不断暴露于呼吸道病原体、毒素和颗粒物，并进化出了非常有效的防御系统来保护自己。粘液纤毛清除是这种防御的重要组成部分，依赖于纤毛上皮、纤毛周围液体的高度和粘液之间的适当相互作用。粘液充当物理屏障，捕获吸入的颗粒和病原体，而纤毛则移动粘液层和下面的纤毛周围层中的液体。这些防御可能会因病毒和细菌感染、吸入毒素以及原发性纤毛运动障碍和囊性纤维化等遗传性疾病而受到破坏。
The lungs and the nasal passages are continually exposed to respiratory pathogens, toxins, and particulate matter, and have evolved a very effective defense system to protect themselves. Mucociliary clearance is an essential part of this defence and relies on appropriate interactions between the ciliated epithelium, the height of the periciliary fluid, and mucus. Mucus acts as a physical barrier, trapping inhaled particles and pathogens, whilst cilia move both the mucus layer and fluid in the underlying periciliary layer. These defenses may be disrupted by viral and bacterial infections, by inhaled toxins, and by inherited diseases such as primary ciliary dyskinesia and cystic fibrosis.