Adrenocortical cells with stem/progenitor cell properties: Recent advances
Adrenocortical cells with stem/progenitor cell properties: Recent advances
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DOI：
10.1016/j.mce.2006.12.028
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发表时间：
2007-02-01
影响因子：
4.1
通讯作者：
Hammer, Gary D.
中科院分区：
文献类型：
--
作者：
Kim, Alex C.;Hammer, Gary D.
长期以来，人们一直在寻找具有维持肾上腺皮质稳态能力的未分化细胞的存在和位置。这些细胞被认为大部分保持静止，有可能致力于自我更新过程或终末分化，以稳态地重新填充器官。此外，响应生理应激，未分化的细胞经历快速增殖以适应器官的需要。通过细胞移植和去核实验已经证明了足够的肾上腺皮质增殖能力持续宿主的寿命。标记实验与氚，BrdU，或台盼蓝，以及转基因检测支持这些未定义的细胞的腺体外周内的克隆形成的身份和位置。我们将未分化的肾上腺皮质细胞定义为缺乏类固醇生成基因表达的细胞，而分化的细胞定义为具有类固醇生成能力的细胞。在这篇综述中，我们讨论了历史的发展研究，以及最近的分子检测，旨在表征这样的细胞群体。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The existence and location of undifferentiated cells with the capability of maintaining the homeostasis of the adrenal cortex have long been sought. These cells are thought to remain mostly quiescent with a potential to commit to self-renewal processes or terminal differentiation to homeostatically repopulate the organ. In addition, in response to physiologic stress, the undifferentiated cells undergo rapid proliferation to accommodate organismic need. Sufficient adrenocortical proliferative capacity lasting the lifespan of the host has been demonstrated through cell transplantation and enucleation experiments. Labeling experiments with tritium, BrdU, or trypan blue, as well as transgenic assays support the clonogenic identity and location of these undefined cells within the gland periphery. We define undifferentiated adrenocortical cells as cells devoid of steroidogenic gene expression, and differentiated cells as cells with steroidogenic capacity. In this review, we discuss historic developmental studies together with recent molecular examinations that aim to characterize such populations of cells. (c) 2006 Elsevier Ireland Ltd. All rights reserved.