Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease
Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease
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DOI：
10.1080/13651501.2017.1306081
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Harkin, Andrew
中科院分区：
文献类型：
--
作者：
Abautret-Daly, Aine;Dempsey, Elaine;Harkin, Andrew
目的：本研究旨在调查炎症介质，症状和心理障碍之间的关联在炎症性肠病（IBD）patients.Methods：IBD患者和患者对照组进行了检查，在一个单一的访问胃肠病诊所。使用溃疡性结肠炎（UC）的马约指数、炎症性肠病问卷（IBDQ）、克罗恩病活动指数（CDAI）和克罗恩病内镜严重程度指数（CDEIS）评估疾病活动性。在肠活检和全血样本中测量炎症介质的基因表达沿着白细胞介素（IL）-6，干扰素（IFN），C-反应蛋白（CRP），犬尿氨酸和色氨酸的循环浓度。经验证的抑郁，焦虑和生活质量的分数被用来评估心理well-being.Results：有症状的患者有最高的抑郁和焦虑的分数，连同增加肠道表达的IL-1，IL-6和基质金属蛋白酶-9，增加循环IL-6和CRP，并增加循环犬尿氨酸：色氨酸的比例。增加汉密尔顿抑郁症（HAM-D）在IBD患者的评分观察独立的心理影响的急性symptoms.Conclusions：积极IBD与抑郁症和焦虑症的症状，并与提高循环炎症介质配置文件。表现出心理症状的活动性IBD患者应接受心理评估，以确保考虑和解决病情的心理方面。
Objective: This study aimed at investigating the associations between inflammatory mediators, symptoms and psychological disturbances in inflammatory bowel disease (IBD) patients.Methods: IBD patients and patient controls were examined during a single visit to a gastroenterology clinic. Disease activity was assessed using the Mayo index for ulcerative colitis (UC), inflammatory bowel disease questionnaire (IBDQ), Crohn's disease activity index (CDAI) and Crohn's disease endoscopic index of severity (CDEIS). Gene expression of inflammatory mediators were measured in intestinal biopsies and whole blood samples along with circulating concentrations of interleukin (IL)-6, interferon (IFN), C-reactive protein (CRP), kynurenine and tryptophan. Validated depression, anxiety and quality of life scores were used to assess psychological well-being.Results: Patients who were symptomatic had the highest depression and anxiety scores, together with increased intestinal expression of IL-1, IL-6 and matrix metalloproteinase-9, increased circulating IL-6 and CRP, and an increased circulating kynurenine:tryptophan ratio. Increased Hamilton depression (HAM-D) scores in IBD patients were observed independent of the psychological impact of acute symptoms.Conclusions: Active IBD is associated with symptoms of depression and anxiety and with a raised circulating inflammatory mediator profile. Patients with active IBD exhibiting psychological symptoms should undergo psychological evaluation to ensure the psychological aspects of the condition are considered and addressed.