Intermittent sulphadoxine-pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial
Intermittent sulphadoxine-pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial
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DOI：
10.1016/s0140-6736(98)07318-8
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发表时间：
1999-02-20
期刊：
影响因子：
168.9
通讯作者：
Marsh, K
中科院分区：
文献类型：
--
作者：
Shulman, CE;Dorman, EK;Marsh, K
背景：在流行传播地区，妊娠期疟疾与严重的孕产妇贫血和低出生体重儿有关。我们在肯尼亚Kilifi地区的初孕妇女中进行了一项双盲安慰剂对照试验，研究了间歇性治疗剂量磺胺嘧啶-乙胺嘧啶在预防妊娠期疟疾和严重贫血方面的疗效。方法1996年1月至1997年4月，1264名初孕妇女参加产前保健，随机分配磺胺嘧啶-乙胺嘧啶（640）或安慰剂（624）。妇女在入组时根据妊娠持续时间接受一剂、两剂或三剂研究药物。主要结局指标为严重贫血（血红蛋白）
Background In areas of endemic transmission, malaria in pregnancy is associated with severe maternal anaemia and low-birthweight babies, We studied the efficacy of intermittent treatment doses of sulphadoxine-pyrimethamine In preventing malaria and severe anaemia in pregnancy in a double-blind placebo-controlled trial among primigravid women living in Kilifi District, Kenya.Methods Between January, 1996, and April, 1997, 1264 primigravid women were recruited when they attended: for antenatal care, and randomly assigned sulphadoxine-pyrimethamine (640) or placebo (624). Women received one, two, or three doses of study medication depending an the duration of gestation at enrolment. Primary outcome measures were severe anaemia (haemoglobin