REDUCTIONS IN BLOOD-PRESSURE, HEART-RATE AND RENAL SYMPATHETIC-NERVE DISCHARGE IN CATS AFTER CENTRAL ADMINISTRATION OF MUSCIMOL, A GABA AGONIST
REDUCTIONS IN BLOOD-PRESSURE, HEART-RATE AND RENAL SYMPATHETIC-NERVE DISCHARGE IN CATS AFTER CENTRAL ADMINISTRATION OF MUSCIMOL, A GABA AGONIST
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DOI：
10.1016/0028-3908(78)90065-5
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发表时间：
1978-01-01
影响因子：
4.7
通讯作者：
TAYLOR, DG
中科院分区：
文献类型：
--
作者：
ANTONACCIO, MJ;KERWIN, L;TAYLOR, DG
蝇蕈醇是一种中枢GABA受体激动剂，当脑室内（i. c. v.）麻醉猫（0.1-1.0 μ g/kg）。在0.3和1.0 μ g/kg（i. c. v.）下抑制肾交感神经放电（RSND）。静脉注射蝇蕈醇后未观察到任何影响。荷包牡丹碱，GABA受体拮抗剂，完全逆转蝇蕈醇对血压，心率和RSND的影响，最一致的，快速和戏剧性的效果后，观察到静脉注射，而不是i. c. v.管理。苦楝素逆转蝇蕈醇的影响，但结果比荷包牡丹碱后更多变。甘氨酸受体拮抗剂士的宁和乙酰胆碱酯酶抑制剂毒扁豆碱对蝇蕈醇的抑制作用无明显影响。蝇蕈醇是更有效的压力感受器失神经猫，比在非失神经猫，可能是由于代偿反射机制的损失。蝇蕈醇对GABA受体的中枢刺激导致血压、心率和RSND显著降低，而GABA受体拮抗剂可特异性拮抗这些效应。
Muscimol, a central GABA receptor agonist, casued dose-related reductions in blood pressure and heart rate when administered intracerebroventricularly (i.c.v.) to anesthetized cats (0.1-1.0 .mu.g/kg). Renal sympathetic nerve discharge (RSND) was inhibited at 0.3 and 1.0 .mu.g/kg (i.c.v.). No effects were observed after the i.v. of muscimol administration. Bicuculline, a GABA receptor antagonist, completely reversed the effects of muscimol on blood pressure, heart rate and RSND, the most consistent, rapid and dramatic effects being observed after i.v. rather than i.c.v. administration. Pictrotoxin reversed the effects of muscimol but the results were more variable than after bicuculline. Strychnine, a glycine receptor antagonist, and physostigmine, an acetylcholinesterase inhibitor, had no significant effects on the inhibition caused by muscimol. Muscimol was even more effective in baroreceptor denervated cats, than in non-denervated cats, probably as a result of the loss of compensatory reflex mechanisms. Central stimulation of GABA receptors by muscimol resulted in marked reductions in blood pressure, heart rate and RSND which were specifically antagonized by GABA receptor antagonists.