Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus
Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus
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DOI：
10.1016/s0006-8993(02)03176-1
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发表时间：
2002-11-22
期刊：
影响因子：
2.9
通讯作者：
Li, XM
中科院分区：
文献类型：
--
作者：
Ashe, PC;Chlan-Fourney, J;Li, XM
越来越多的证据表明，精神分裂症是一种以症状恶化和大脑形态改变为特征的进行性神经发育障碍。这表明精神分裂症中可能存在神经退行性成分。脑源性神经营养因子（BDNF）在神经发育、细胞活力和突触可塑性中的作用促使BDNF作为精神分裂症病理生理中的潜在候选分子被研究。BDNF mRNA在新生儿腹侧海马伊博tenic酸损伤动物的前额皮质和海马中进行原位杂交检测，腹侧海马被认为是精神分裂症的神经发育动物模型。结果表明，新生儿海马腹侧伊博tenic酸损伤的动物BDNF mRNA的基础水平降低。可能是这种营养因子的改变使动物更容易受到神经退行性损伤。(C) 2002年Elsevier Science B.V.出版
Increasing evidence suggests that schizophrenia is a neurodevelopmental disorder with a progressive course characterized by worsening of symptoms and morphological alterations within the brain. This suggests that a neurodegenerative component may exist in schizophrenia. The role of brain-derived neurotrophic factor (BDNF) in neurodevelopment, cell viability and synaptic plasticity led to the investigation of BDNF as a potential candidate molecule in the pathophysiology of schizophrenia. BDNF mRNA was examined by in situ hybridization in the prefrontal cortex and hippocampus of animals with neonatal ibotenic acid lesions of the ventral hippocampus, a putative neurodevelopmental animal model of schizophrenia. Results demonstrate that animals with neonatal ibotenic acid lesions of the ventral hippocampus have reduced basal levels of BDNF mRNA. It is possible that alterations in this trophic factor render animals more susceptible to neurodegenerative insults. (C) 2002 Published by Elsevier Science B.V.