Coming of age? Neuroimaging biomarkers in youth.
Coming of age? Neuroimaging biomarkers in youth.
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成年了吗？
DOI：
10.1176/appi.ajp.2009.09101546
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Phillips,MaryL
中科院分区：
文献类型：
--
作者：
Phillips,MaryL
精神疾病的诊断通常是通过评估行为和对异常经历的主观报告来将个体分为疾病类别。然而，这些类别掩盖了大量的异质性，特别是在儿童发病的精神疾病，如双相情感障碍，这种疾病仍然难以与其他青年精神疾病区分开来。在缺乏客观的生物标志物的情况下，精神疾病的诊断准确性仍然受到严重影响。在本期杂志中，Brotman及其同事（1）提供了初步证据，表明特定的神经影像学措施可以帮助区分青少年双相情感障碍与青少年注意缺陷多动障碍（ADHD）和严重的情绪调节障碍，其特征是慢性，非发作性表现为明显的易怒和过度觉醒（2）。因此，这些发现凸显了神经成像技术在识别青少年精神疾病生物标志物方面的未来前景。
Diagnosis of psychiatric illnesses is conventionally made by evaluating behavior and subjective report of abnormal experiences to group individuals into illness categories. These categories mask a great deal of heterogeneity, however, particularly in child-onset psychiatric illnesses such as bipolar disorder, an illness that remains notoriously difficult to differentiate from other psychiatric illnesses in youth. In the absence of objective biological markers—“biomarkers”—diagnostic accuracy for psychiatric illnesses therefore remains severely compromised. In this issue of the Journal, Brotman and colleagues (1) provide preliminary evidence that specific neuroimaging measures can help distinguish youth with bipolar disorder from youth with attention deficit hyperactivity disorder (ADHD) and severe mood dysregulation characterized by chronic, nonepisodic presentations of marked irritability and hyperarousal (2). These findings thereby highlight the future promise of neuroimaging to identify biomarkers of psychiatric illnesses in youth.