Peroxisomal β-oxidation enzymes
Peroxisomal β-oxidation enzymes
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DOI：
10.1023/a:1022540030918
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发表时间：
1999-04-01
影响因子：
4.4
通讯作者：
Hashimoto, T
中科院分区：
文献类型：
--
作者：
Hashimoto, T
参与β-氧化螺旋的酶被示意性地分为两组。第一组由棕榈酰-CoA氧化酶（L-双功能蛋白，其被称为双功能蛋白）和3-酮脂酰-CoA硫解酶组成。第二组由新确认的酶、支链氧化酶、D-双功能蛋白和固醇载体蛋白X组成。第一组酶是诱导型的，作用于直链酰基辅酶A底物。但第二组酶是不可诱导的，作用于支链酰基辅酶A。因此，胆汁酸的形成和由植醇衍生的降植烷酸的氧化由第二组酶催化，但不由第一组酶催化。本文简要介绍了过氧化物酶体系统的功能和酶的分析方法。
The enzymes involved in beta-oxidation spiral are schematically classified into two groups. The first group consists of palmitoyl-CoA oxidase, the L-bifunctional protein, which has been called as the bifunctional protein, and 3-ketoacyl-CoA thiolase. The second group consists of the newly confirmed enzymes, branched chain oxidase, the D-bifunctional protein, and sterol carrier protein x. The enzymes of the first group are inducible and act on the straight chain acyl-CoA substrates. But the enzymes of the second group are non-inducible and act on branched chain acyl-CoAs. Accordingly, bile acid formation and oxidation of pristanic acid derived from phytol are catalyzed by the enzymes of the second group but not by those of the first group. The functions of the peroxisomal system and methods of analysis of the enzymes are briefly summarized.