Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs
Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with haplotype-tagging SNPs
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DOI：
10.1086/422853
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发表时间：
2004-08-01
影响因子：
9.8
通讯作者：
Nakamura, Y
中科院分区：
文献类型：
--
作者：
Kamatani, N;Sekine, A;Nakamura, Y
为了优化基于人群的药物遗传学研究的策略，我们广泛分析了199个药物相关基因的单核苷酸多态性（SNP）和单倍型，通过使用752名对照受试者的4，190个SNP。与其他基因一样，药物相关基因具有单倍型块结构，并且少数单倍型标记SNPs（htSNPs）可以代表由块中的共同SNPs构建的大多数主要单倍型。因为我们的数据包括860个不常见的（频率
To optimize the strategies for population-based pharmacogenetic studies, we extensively analyzed single-nucleotide polymorphisms (SNPs) and haplotypes in 199 drug-related genes, through use of 4,190 SNPs in 752 control subjects. Drug-related genes, like other genes, have a haplotype-block structure, and a few haplotype-tagging SNPs (htSNPs) could represent most of the major haplotypes constructed with common SNPs in a block. Because our data included 860 uncommon (frequency