Polypoidal choroidal vasculopathy and treatments
Polypoidal choroidal vasculopathy and treatments
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DOI：
10.1097/icu.0b013e3282fb7c33
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发表时间：
2008-05-01
影响因子：
3.7
通讯作者：
Tano, Yasuo
中科院分区：
文献类型：
--
作者：
Gomi, Fumi;Tano, Yasuo
综述目的本综述评估了目前对息肉状脉络膜血管病变的临床特征和治疗的了解。最新发现息肉状脉络膜血管病变是一种具有特征性脉络膜血管异常的疾病。吲哚菁绿血管造影对于诊断至关重要。亚洲人的患病率高于白种人。光动力疗法对治疗息肉状脉络膜血管病变有效；一年的结果表明，光动力疗法比年龄相关性黄斑变性继发的脉络膜新生血管的益处更大。然而，在光动力治疗后的随访期间，复发会严重影响长期视力。贝伐珠单抗（一种血管内皮生长因子的全长抗体）已被证明对息肉状脉络膜血管病变的疗效较低。总结尽管已知息肉状脉络膜血管病变和年龄相关性黄斑变性具有共同的遗传因素，但其临床特征（包括对光动力治疗的不同反应）表明，息肉状脉络膜血管病变是与年龄相关性黄斑变性不同的临床实体。光动力疗法治疗息肉状脉络膜血管病变的结果令人鼓舞；然而，随着时间的推移，复发可能会影响视力。需要抑制息肉状脉络膜血管病的渗出性脉络膜血管系统发展的治疗方式。
Purpose of reviewThis review assesses the current knowledge of the clinical characteristics of polypoidal choroidal vasculopathy and treatments.Recent findingsPolypoidal choroidal vasculopathy is a disease with characteristic choroidal vascular abnormalities. Indocyanine green angiography is essential for diagnosis. The prevalence is higher in Asian people than in Caucasians. Photodynamic therapy is efficacious for treating polypoidal choroidal vasculopathy; 1-year results have shown greater benefit of photodynamic therapy than choroidal neovascularization secondary to age-related macular degeneration. Recurrence, however, seriously affects vision long term during follow-up after photodynamic therapy. The lower efficacy of bevacizumab- a full-length antibody of vascular endothelial growth factor- has been shown for polypoidal choroidal vasculopathy.SummaryAlthough the polypoidal choroidal vasculopathy and age-related macular degeneration have been known to share common genetic factors, its clinical characteristics including the different responses to photodynamic therapy suggest that polypoidal choroidal vasculopathy is a separate clinical entity from age-related macular degeneration. The results of photodynamic therapy for polypoidal choroidal vasculopathy are encouraging; however, recurrence may affect vision over time. Therapeutic modalities to inhibit development of the exudative choroidal vasculature of polypoidal choroidal vasculopathy are desirable.