LIFE-STYLE AND BIOLOGIC FACTORS ASSOCIATED WITH ATHEROSCLEROTIC DISEASE IN MIDDLE-AGED MEN - 20-YEAR FINDINGS FROM THE HONOLULU HEART PROGRAM
LIFE-STYLE AND BIOLOGIC FACTORS ASSOCIATED WITH ATHEROSCLEROTIC DISEASE IN MIDDLE-AGED MEN - 20-YEAR FINDINGS FROM THE HONOLULU HEART PROGRAM
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DOI：
10.1001/archinte.155.7.686
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发表时间：
1995-04-10
影响因子：
--
通讯作者：
YANO, K
中科院分区：
文献类型：
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作者：
GOLDBERG, RJ;BURCHFIEL, CM;YANO, K
目的：在一个中年日裔美国男性队列中研究各种基线生活方式和生物因素与总动脉粥样硬化终点的20年发病率和该疾病的每种初始临床表现（包括致命性和非致命性冠心病、心绞痛、血栓栓塞性中风和主动脉瘤）之间的相关性。设计：前瞻性流行病学研究。在檀香山心脏项目的初始临床检查时，年龄介于SS和64岁之间的日裔美国男性（N=2710）（1965年至1968年）无冠心病、脑血管疾病、癌症或主动脉瘤的证据。在研究的男性中，在23年的随访期间（1965年至1988年）发生了602例动脉粥样硬化事件。在对每一个基线特征进行校正后，观察到体重指数、收缩压、血清胆固醇、甘油三酯、葡萄糖和尿酸水平以及吸烟的四分位数临界值与任何动脉粥样硬化终点的发生之间存在显著的正相关，而与酒精呈负相关。消费观察。与该队列中其他致死性和非致死性临床事件（包括冠心病、血栓栓塞性卒中和主动脉瘤）的发生相关的特征与伴随的相对和归因风险一起呈现。这项前瞻性流行病学研究的结果为长期的长期预测效用的普遍接受的危险因素，冠心病有关的不同临床表现的动脉粥样硬化，在一个中期-老年男性队列随访约20年。这些结果为中年男性的风险因素调整和鼓励积极的长期生活方式改变提供了额外的支持，
Objectives: To examine the association between a variety of baseline lifestyle and biologic factors in a middle-aged cohort of Japanese-American men and the 20-year incidence rates of total atherosclerotic end points and each of the initial clinical manifestations of this disease, including fatal and nonfatal coronary heart disease, angina pectoris, thromboembolic strokes, and aortic aneurysms.Design: Prospective epidemiologic study.Population:Japanese-American men (N=2710) between the ages of SS and 64 years at the time of the initial clinical examination of the Honolulu Heart Program (1965 through 1968) free from evidence of coronary heart disease, cerebrovascular disease, cancer, or aortic aneurysms.Results: Among the men studied, 602 atherosclerotic events developed during the 23-year period of follow-up (1965 through 1988). After adjustment for each of the baseline characteristics examined, significant positive associations between quartile cutoffs of body mass index, systolic blood pressure, serum levels of cholesterol, triglycerides, glucose, and uric acid, as well as cigarette smoking, and the occurrence of any atherosclerotic end point were seen, while an inverse association with alcohol. consumption was observed. Characteristics associated with the development of other fatal and nonfatal clinical events in this cohort, including coronary heart disease, thromboembolic stroke, and aortic aneurysms are presented with accompanying relative and attributable risks.Conclusions: The results of this prospective epidemiologic study provide insights to the long-term predictive utility of the commonly accepted risk factors for coronary heart disease in relation to the different clinical manifestations of atherosclerosis in a middle-aged male cohort followed up for approximately 20 years. These results provide additional support for risk factor modification in middle-aged men and for the encouragement of positive long-term lifestyle changes,