Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan
Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan
复制标题
DOI：
10.2307/3434992
复制
发表时间：
2000-09-01
影响因子：
10.4
通讯作者：
Chen, CJ
中科院分区：
文献类型：
--
作者：
Tseng, CH;Tai, TY;Chen, CJ
据报道，台湾砷病高发村庄的糖尿病患病率明显高于一般人群。这项队列研究的目的是进一步评估这些村庄摄入的无机砷与非胰岛素依赖型糖尿病发病率之间的关系。这些村庄共有 446 名非糖尿病居民每两年接受一次口服葡萄糖耐量试验。糖尿病的定义是空腹血糖水平大于或等于 7.8 mmol/L 和/或负荷后 2 小时血糖水平大于或等于 11.1 mmol/L。在1499.5人年的随访期间，41例患糖尿病，总体发病率为27.4/1000人年。糖尿病的发病率与年龄、体重指数和累积砷暴露相关。年龄大于或等于 55 岁与 < 55 岁、体重指数大于或等于 25 与 < 25 kg/m(2) 以及累积砷暴露量大于或等于 17 与 < 17 mg/L 年的多变量调整相对风险分别为 1.6、2.3 和 2.1。 35-44岁、45-54岁、55-64岁和55-64岁年龄组的发病密度比（95%置信区间）分别为3.6（3.5-3.6）、2.3（1.1-4.9）、4.3（2.4-7.7）和5.5（2.2-13.5）。 65-74岁。这些发现与我们之前的横断面观察一致，即摄入无机砷会导致人类糖尿病。
Diabetes prevalence in arseniasis-hyperendemic villages in Taiwan has been reported to be significantly higher than in the general population. The aim of this cohort study was to further evaluate the association between ingested inorganic arsenic and the incidence of non-insulin-dependent diabetes mellitus in these villages. A total of 446 nondiabetic residents in these villages were followed biannually by oral glucose tolerance test. Diabetes is defined as a fasting plasma glucose level greater than or equal to 7.8 mmol/L andlor a 2-hr post-load glucose level greater than or equal to 11.1 mmol/L. During the follow-up period of 1499.5 person-years, 41 cases developed diabetes, showing an overall incidence of 27.4/1,000 person-years. The incidence of diabetes correlated with age, body mass index, and cumulative arsenic exposure. The multivariate-adjusted relative risks were 1.6, 2.3, and 2.1 for age greater than or equal to 55 versus < 55 years, a body mass index greater than or equal to 25 versus < 25 kg/m(2), and a cumulative arsenic exposure greater than or equal to 17 versus < 17 mg/L-years, respectively. The incidence density ratios (95% confidence intervals) between the hyperendemic villages and the two nonendemic control townships were 3.6 (3.5-3.6), 2.3 (1.1-4.9), 4.3 (2.4-7.7), and 5.5 (2.2-13.5), respectively, for the age groups of 35-44, 45-54, 55-64, and 65-74 years. The findings are consistent with our previous cross-sectional observation that ingested inorganic arsenic is diabetogenic in human beings.