Alginate/chitosan particulate systems for sodium diclofenac release
Alginate/chitosan particulate systems for sodium diclofenac release
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DOI：
10.1016/s0378-5173(01)00915-2
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发表时间：
2002-01-31
影响因子：
5.8
通讯作者：
Fini, A
中科院分区：
文献类型：
--
作者：
González-Rodríguez, ML;Holgado, MA;Fini, A
Alginate/chitosan particles were prepared by ionic gelation (Ca2+ and Al3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH. while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
