25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey
25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey
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DOI：
10.1016/j.atherosclerosis.2008.10.033
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发表时间：
2009-07-01
期刊：
影响因子：
5.3
通讯作者：
Chonchol, Michel
中科院分区：
文献类型：
--
作者：
Kendrick, Jessica;Targher, Giovanni;Chonchol, Michel
目的：血清25-羟基维生素D [25（OH）D]水平与重要的心血管疾病（CVD）危险因素呈负相关。然而，25（OH）D水平与心血管疾病患病率之间的关系尚未在普通人群中得到广泛研究。我们对第三次全国健康与营养调查的数据进行了横断面分析（1988-1994），并在16例代表性人群样本中检查了血清25（OH）D水平与CVD患病率之间的关系，603名18岁或以上的男女。心血管疾病的患病率被定义为一个复合措施，包括自我报告的心绞痛，心肌梗死或stroke.Results：在整个人群中，有1308（8%）与自我报告的心血管疾病的主题。心血管病患者25（OH）D缺乏的频率更高[定义为血清25（OH）D水平
Objective: Serum 25-hydroxyvitamin D [25(OH)D] levels are inversely associated with important cardiovascular disease (CVD) risk factors. However, the association between 25(OH)D levels and prevalent CVD has not been extensively examined in the general population.Methods: We performed a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (1988-1994) and examined the association between serum 25(OH)D levels and prevalence of CVD in a representative population-based sample of 16,603 men and women aged 18 years or older. Prevalence of CVD was defined as a composite measure inclusive of self-reported angina, myocardial infarction or stroke.Results: In the whole population, there were 1308 (8%) subjects with self-reported CVD. Participants with CVD had a greater frequency of 25(OH)D deficiency [defined as serum 25(OH)D levels