Decreased cortisol levels in adolescent girls with conduct disorder
Decreased cortisol levels in adolescent girls with conduct disorder
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DOI：
10.1001/archpsyc.58.3.297
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发表时间：
2001-03-01
影响因子：
--
通讯作者：
Neal, S
中科院分区：
文献类型：
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作者：
Pajer, K;Gardner, W;Neal, S
背景：女性青少年反社会行为正在增加，但对这种疾病的神经内分泌方面知之甚少。基于反社会男性皮质醇水平降低的报道，我们调查了患有品行障碍（CD）的青春期女孩早晨血浆皮质醇水平。方法：在47名患有CD的青春期女孩中，在上午8点至9点之间每20分钟采集三份血浆样本用于皮质醇水平（平均年龄+/- SD，16.5 +/- 0.9岁）和37名正常对照女孩（平均年龄，16.0 +/- 0.8岁）。所有的血液在月经开始后72小时内抽取。结果：CD女孩在所有3个采样时间的皮质醇水平均显著低于正常对照组女孩。这一发现不是由于手术因素、人口统计学特征或药物使用所致。没有其他精神问题的CD女孩的皮质醇水平低于其他疾病或正常对照组的女孩。在多元回归分析中，CD预测10%的变异在皮质醇level.Conclusions：早晨血浆皮质醇水平显着减少，在青春期女孩CD。皮质醇水平下降似乎与没有其他精神疾病的反社会女孩最密切相关。
Background: Female adolescent antisocial behavior is increasing, but little is known about the neuroendocrinologic aspects of this disorder. On the basis of reports of decreased cortisol levels in antisocial males, we investigated morning plasma cortisol levels in adolescent girls with conduct disorder (CD).Methods: Three plasma samples for cortisol levels were taken every 20 minutes between 8 and 9 AM in 47 adolescent girls with CD (mean +/- SD age, 16.5 +/- 0.9 years) and 37 normal control girls (mean age, 16.0 +/- 0.8 years). All blood was drawn within 72 hours after the onset of menstrual flow.Results: Girls with CD had significantly lower cortisol levels than girls in the normal control group at all 3 sampling times. This finding was not due to procedural factors, demographic characteristics, or the use of medications. The girls with CD who had no other psychiatric problems had lower cortisol levels than girls with other disorders or those in the normal control group. In the multiple regression analysis, having CD predicted 10% of the variance in cortisol levels.Conclusions: Morning plasma cortisol levels were significantly diminished in adolescent girls with CD. Decreased cortisol levels appear to be most strongly associated with antisocial girls who do not have other psychiatric disorders.