A SALIVARY GLAND-SPECIFIC, MALTASE-LIKE GENE OF THE VECTOR MOSQUITO, AEDES-AEGYPTI
A SALIVARY GLAND-SPECIFIC, MALTASE-LIKE GENE OF THE VECTOR MOSQUITO, AEDES-AEGYPTI
复制标题
DOI：
10.1016/0378-1119(89)90384-3
复制
发表时间：
1989-01-30
期刊：
影响因子：
3.5
通讯作者：
RACIOPPI, JV
中科院分区：
文献类型：
--
作者：
JAMES, AA;BLACKMER, K;RACIOPPI, JV
已分离并测序了在成年埃及伊蚊唾液腺中特异性表达的基因的基因组和cDNA克隆。该基因编码大量mRNA，其在整个雄性唾液腺中转录，但仅在雌性腺体的近侧叶的细胞中转录。推导出的蛋白质有许多基本的氨基酸，几个可能的N-糖基化位点，并显示出惊人的相似性与酵母麦芽糖酶基因和三个以前未鉴定的基因从果蝇的产品。我们建议将该基因命名为Maltase-like I（MalI）。这种基因产物的假定功能是帮助蚊子提高其进食糖的能力。蚊子和果蝇基因在蛋白质编码区的5“端具有相似的结构特征，表明这些基因可能具有共同的控制机制。
Genomic and cDNA clones of a gene expressed specifically in the salivary glands of adult Aedes aegypti have been isolated and sequenced. This gene encodes an abundant mRNA that is transcribed throughout the male salivary gland but only in the cells of the proximal lateral lobes of the female gland. The deduced protein has many basic amino acids, several possible sites for N-glycosylation, and displays striking similarities with the products of a yeast maltase gene and three previously unidentified genes from Drosophila melanogaster. We propose the name ''Maltase-like I'' (MalI) to designate this gene. The presumed function of this gene product is to assist the mosquito in its sugar-feeding capabilities. The mosquito and fruitfly gene have similar structural features 5'' to the protein coding regions, indicating that these genes may share common control mechanisms.