In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain
In vivo effect of antidepressants on [3H]paroxetine binding to serotonin transporters in rat brain
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DOI：
10.1007/s11064-008-9703-z
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发表时间：
2008-11-01
影响因子：
4.4
通讯作者：
Malviya, Manish
中科院分区：
文献类型：
--
作者：
Nadgir, Subhash M.;Malviya, Manish
胺转运体是开发各种药物治疗行为障碍的主要靶点。5-羟色胺转运体(SERT)与抑郁症的病因有关，作用于SERT的药物可有效治疗抑郁症。本研究旨在研究不同抗抑郁药对大鼠脑区[H-3]帕罗西汀与SERT结合的影响。用阿米替林等三环类抗抑郁药(TCAs)、氯丙咪嗪(CMI)等5-羟色胺/去甲肾上腺素再摄取抑制剂(SNRI)、氟西汀(Floxetine)和西酞普兰(CIT)等选择性5-羟色胺再摄取抑制剂(SSRIs)(10 mg/kg体重)治疗大鼠。30天。用[H-3]帕罗西汀(0.03-1.0 NM)作替换剂，在存在和不存在10亩M氟西汀的情况下，测定大脑皮质和海马区SERT密度。CMI组大鼠大脑皮质SERT密度显著降低(68%，P
Amine transporters are major target for development of various pharmacological agents to treat behavioral disorders. Serotonin transporters (SERT) have been implicated in the etiology of depression and drugs acting on SERT can be effective in treating depression. The aim of the present study was to study the in vivo effect of various antidepressants on [H-3] paroxetine binding to SERT in regions of rat brain. Rats were treated with tricyclic antidepressant (TCAs) such as amitriptyline (AMI), serotonin/ norepinephrine reuptake inhibitor (SNRIs) such as clomipramine (CMI), and selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (FLX) and citalopram (CIT) (10 mg/kg body wt.) for 30 days. Density of SERT was measured in cortex and hippocampus using [H-3] paroxetine (0.03-1.0 nM) in presence and absence of 10 mu M fluoxetine as displacer. It was observed that the density of cortical SERT was significantly decreased with CMI (68%, P