A high frequency of allergen‐specific CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl
A high frequency of allergen‐specific
CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl
复制标题
高频率的过敏原特异性 CD8+ Tc1 细胞与小鼠对接触敏化剂三硝基苯的免疫反应有关
作者：
Stefan F. Martin;V. Delattre;C. Leicht;H. Weltzien;J. Simon
摘要：化学半抗原通过诱导半抗原特异性 T 细胞诱导多种过敏性免疫反应。半抗原三硝基氯苯 (TNCB) 等接触敏化剂会引起过敏反应，该反应仅限于抗原暴露区域。尽管存在这种局部过敏反应，但我们在此表明，三硝基苯基（TNP）特异性免疫反应的特点是在接触单一过敏原后就快速诱导 CD8+ Tc1 型细胞毒性效应细胞，这可以在所有测试的次级淋巴器官中检测到。我们进一步证明，CD8+ Tc1 效应细胞的快速诱导与异常高频率的多克隆 TNP 特异性 CD8+ 效应 T 细胞相关，这些细胞对多种在不同位置携带半抗原的 MHC I 类结合 TNP 肽具有特异性。这些数据表明，对化学半抗原的过敏可能部分是由于在所有次级淋巴器官中检测到的多克隆、过敏原特异性效应细胞的频率异常高。
Abstract: Chemical haptens induce a variety of allergic immune reactions by induction of hapten‐specific T cells. Contact sensitizers such as the hapten trinitrochlorobenzene (TNCB) elicit an allergic response, which is confined to the area of antigen exposure. Despite this localized allergic response, we show here that the trinitrophenyl (TNP)‐specific immune response is characterized by a rapid induction of CD8+ Tc1 type cytotoxic effector cells already after a single allergen contact which can be detected in all secondary lymphoid organs tested. We furthermore demonstrate that the rapid induction of CD8+ Tc1 effector cells correlates with an unusually high frequency of polyclonal TNP‐specific CD8+ effector T cells with specificities for a variety of MHC class I binding TNP‐peptides carrying the hapten in different positions. These data suggest that allergies to chemical haptens may in part be due to an unusually high frequency of polyclonal, allergen‐specific effector cells which are detected in all secondary lymphoid organs.
影响因子：
2.2
作者：
T. Taguchi;J. Mcghee;R. Coffman;K. Beagley;J. Eldridge;K. Takatsu;H. Kiyono
通讯作者：
T. Taguchi;J. Mcghee;R. Coffman;K. Beagley;J. Eldridge;K. Takatsu;H. Kiyono