Phenylpropanoid and lignan glycosides from the aerial parts of Lespedeza cuneata
Phenylpropanoid and lignan glycosides from the aerial parts of Lespedeza cuneata
复制标题
胡枝子地上部分的苯丙素和木酚素苷
DOI：
10.1016/j.phytochem.2015.10.002
复制
发表时间：
2016-01-01
期刊：
影响因子：
3.8
通讯作者：
Zhang, Dong-Ming
中科院分区：
文献类型：
--
作者：
Zhou, Jian;Li, Chuang-Jun;Zhang, Dong-Ming
从截叶胡枝子（Lespedeza cuneata）地上部分分得4个苯丙素苷（1-4）和5个木脂素苷（5-9），以及3个已知的木脂素苷（10-12）。化合物5-9的绝对构型由圆二色光谱确定。此外，测试化合物激活xbp 1启动子上的转录效应的能力。化合物4、5、7、9、10和12可不同程度地激活xbp 1的转录，其EC 50值范围为0.18 - 0.64 μ M。(C)2015爱思唯尔有限公司版权所有。
Four phenylpropanoid glucosides (1-4) and five lignan glycosides (5-9) were isolated from the aerial parts of Lespedeza cuneata, together with three known lignan glycosides (10-12). Their structures were elucidated on the basis of spectroscopic analyses, and the absolute configurations of compounds 5-9 were determined from the CD spectra. In addition, the compounds were tested for their ability to activate the transcription effect on xbp1 promoter. Compounds 4, 5, 7, 9, 10, and 12 could activate the transcription of xbp1 to varying degrees, with EC50 values ranging from 0.18 to 0.64 mu M. (C) 2015 Elsevier Ltd. All rights reserved.