A Hippocampus-Inspired Dual-Gated Organic Artificial Synapse for Simultaneous Sensing of a Neurotransmitter and Light
A Hippocampus-Inspired Dual-Gated Organic Artificial Synapse for Simultaneous Sensing of a Neurotransmitter and Light
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DOI：
10.1002/adma.202100119
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发表时间：
2021-03-22
影响因子：
29.4
通讯作者：
Oh, Joon Hak
中科院分区：
文献类型：
--
作者：
Lee, Hae Rang;Lee, Doyoung;Oh, Joon Hak
模拟人类化学突触和感觉感知功能的有机神经形态器件和传感器在下一代计算和集成逻辑电路中受到了广泛关注。尽管最近的进展，有机人工突触能够检测在液体环境和光的神经递质没有报告。在此，受海马突触的启发，开发了具有光电导聚合物半导体、P（VDF-TrFE）铁电绝缘体和用硼酸功能化的扩展栅电极的双栅极有机突触晶体管平台，以同时检测神经递质多巴胺和光。开发的突触晶体管使记忆巩固后，反复暴露于多巴胺和多色光，表现出有效调制的突触后电流。这种结合了化学传感器和光电传感器的概念验证的神经元-突触-模拟有机神经形态系统为开发低功耗有机人工突触多传感器和光诱导记忆巩固人工突触开辟了新的可能性，并且还可以有助于人机界面的开发。
Organic neuromorphic devices and sensors that mimic the functions of chemical synapses and sensory perception in humans have received much attention for next-generation computing and integrated logic circuits. Despite recent advances, organic artificial synapses capable of detecting both neurotransmitters in liquid environments and light are not reported. Herein, inspired by hippocampal synapses, a dual-gate organic synaptic transistor platform with a photoconductive polymer semiconductor, a ferroelectric insulator of P(VDF-TrFE), and an extended-gate electrode functionalized with boronic acid is developed to simultaneously detect the neurotransmitter dopamine and light. The developed synaptic transistor enables memory consolidation upon repetitive exposure to dopamine and polychromatic light, exhibiting effectively modulated postsynaptic currents. This proof-of-concept hippocampal-synapse-mimetic organic neuromorphic system combining a chemical sensor and a photosensor opens new possibilities for developing low-power organic artificial synaptic multisensors and light-induced memory consolidative artificial synapses, and can also contribute to the development of human-machine interfaces.