The association of plasma fibrinogen with the extent and complexity of coronary lesions in patients with acute coronary syndrome
The association of plasma fibrinogen with the extent and complexity of coronary lesions in patients with acute coronary syndrome
复制标题
DOI：
10.5603/kp.a2015.0196
复制
发表时间：
2016-01-01
影响因子：
3.3
通讯作者：
Aksoy, Ozlem
中科院分区：
文献类型：
--
作者：
Kurtul, Alparslan;Yarlioglues, Mikail;Aksoy, Ozlem
背景：在急性冠状动脉综合征（ACS）患者中，高SXscore（SXscore）与更严重的疾病和更差的预后相关。血浆纤维蛋白原水平与不良心血管结局相关。目的：探讨ACS患者入院时纤维蛋白原水平与中-高SX评分的关系。方法：共纳入752例ACS患者（61.6 ± 12.8岁，67.3%为男性），均行急诊冠状动脉造影（CAG）。CAG前检测纤维蛋白原和超敏C反应蛋白。所有患者的CAG评分均从基线开始计算。结果：入院时纤维蛋白原水平在SXscore ≥ 23组明显高于SXscore 417 mg/dL组，其预测中-高SXscore的敏感性为80.0%，特异性为71.3%。
Background: High Syntax score (SXscore) is associated with more serious disease and worse prognosis in patients with acute coronary syndrome (ACS). Plasma fibrinogen levels are associated with poor cardiovascular outcomes.Aim: To investigate the relation of admission fibrinogen levels with intermediate-high SXscore in patients with ACS.Methods: A total of 752 patients (61.6 +/- 12.8 years, 67.3% men) with ACS, who underwent urgent coronary angiography (CAG) were enrolled. Laboratory data including fibrinogen and high sensitivity C-reactive protein were obtained before CAG. Syntax scores of all patients were calculated from baseline CAG. The patients were divided into two groups: low SXscore (= 23).Results: Admission fibrinogen levels were significantly higher in the SXscore >= 23 group when compared with the SXscore 417 mg/dL had an 80.0% sensitivity and 71.3% specificity in predicting intermediate-high SXscore.Conclusions: Increased fibrinogen levels are independently associated with intermediate-high SXscore in patients with ACS.